7α-Thiomethylspironolactone sulfoxide

7α-Thiomethylspironolactone sulfoxide
Clinical data
Other names7α-TMS sulfoxide; 7α-Thiomethylspironolactone S-oxide; 7α-Methylsulfinylspironolactone
Identifiers
  • (7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-7-methylsulfinylspiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H32O4S
Molar mass404.57 g·mol−1
3D model (JSmol)
  • C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CCC(=O)O5)C)S(=O)C
  • InChI=1S/C23H32O4S/c1-21-8-4-15(24)12-14(21)13-18(28(3)26)20-16(21)5-9-22(2)17(20)6-10-23(22)11-7-19(25)27-23/h12,16-18,20H,4-11,13H2,1-3H3/t16-,17-,18+,20+,21-,22-,23+,28?/m0/s1
  • Key:ADVFYBFTUKGFGC-FLWPULIFSA-N

7α-Thiomethylspironolactone sulfoxide (also known as 7α-TMS sulfoxide, 7α-thiomethylspironolactone S-oxide, or 7α-methylsulfinylspironolactone) is a metabolite of spironolactone (brand name Aldactone), an antimineralocorticoid and antiandrogen medication.[1][2][3][4][5][6] 7α-TMS sulfoxide is specifically formed from 7α-thiomethylspironolactone (7α-TMS).[1][2][4][3][5][6]

References

  1. ^ a b Cashman JR, Peña S (1988). "S-oxygenation of 7 alpha-thiomethylspironolactone by the flavin-containing monooxygenase". Drug Metabolism and Drug Interactions. 6 (3–4): 337–348. doi:10.1515/dmdi.1988.6.3-4.337. PMID 3271645. S2CID 87034365.
  2. ^ a b Mohrke W, Ullrich F (6 December 2012). "Metabolism of Diuretics". In Greger RF, Knauf H, Mutschler E (eds.). Diuretics. Springer Science & Business Media. pp. 194–. ISBN 978-3-642-79565-7.
  3. ^ a b Al-Hadiya BM, Belal F, Asiri YA, Gubara OA (2002). Spironolactone. Analytical Profiles of Drug Substances and Excipients. Vol. 29. Academic Press. pp. 261–320. doi:10.1016/S1075-6280(02)29009-6. ISBN 9780122608292. ISSN 1075-6280.
  4. ^ a b Abshagen U, Rennekamp H, Luszpinski G (December 1976). "Pharmacokinetics of spironolactone in man". Naunyn-Schmiedeberg's Archives of Pharmacology. 296 (1): 37–45. doi:10.1007/BF00498838. PMID 1012347. S2CID 21225731.
  5. ^ a b Overdiek HW, Merkus FW (1987). "The metabolism and biopharmaceutics of spironolactone in man". Reviews on Drug Metabolism and Drug Interactions. 5 (4): 273–302. doi:10.1515/DMDI.1987.5.4.273. PMID 3333882. S2CID 29482256.
  6. ^ a b Cashman JR, Peña S (1989). "Canrenone formation via general-base-catalyzed elimination of 7 alpha-(methylthio)spironolactone S-oxide". Chemical Research in Toxicology. 2 (2): 109–113. doi:10.1021/tx00008a007. PMID 2519709.
Stub icon

This article about a steroid is a stub. You can help Wikipedia by expanding it.

Read other articles:

Jalan Tol Solo–Ngawi

Jalan Tol Solo-NgawiInformasi ruteBagian dari Jalan Tol Trans-JawaDikelola oleh PT Jasamarga Solo Ngawi (JSN)Panjang:90 km (56 mi)Berdiri:16 Juli 2018; 5 tahun lalu (2018-07-16) – sekarangPersimpangan besarDari: Jalan Tol Semarang-Solo Jalan Tol Solo-Yogyakarta-YIA Kulonprogo Simpang Susun Colomadu JunctionSimpang Susun Bandara Adi SoemarmoSimpang Susun NgemplakSimpang Susun GondangrejoSimpang Susun KaranganyarSimpang Susun SragenSimpang Susun Sragen TimurSimpang Susun NgawiK...

 

David Belasco

David BelascoLahir(1853-07-25)25 Juli 1853San Francisco, California, Amerika SerikatMeninggal14 Mei 1931(1931-05-14) (umur 77)Manhattan, New York City, Amerika SerikatPekerjaanProduser teatrikal, pengarah, pengarang dramaTahun aktif1884 sampai 1930Karya terkenalMadame ButterflySuami/istriCecilia Loverich ​ ​(m. 1873; kematiannya 1926)​ David Belasco (25 Juli 1853 – 14 Mei 1931) adalah seorang produser teatrikal, impres...

 

Menara Syahbandar

Menara Syahbandar (Uitkijk) dibangun sekitar tahun 1839 yang berfungsi sebagai menara pemantau bagi kapal-kapal yang keluar-masuk Kota Batavia lewat jalur laut serta berfungsi kantor pabean yakni mengumpulkan pajak atas barang-barang yang dibongkar di pelabuhan Sunda Kelapa. Menara ini sebenarnya menempati bekas bastion (selekoh) Culemborg yang dibangun sekitar 1645, seiring pembuatan tembok keliling kota di tepi barat. Sebelum dibangun Menara Syahbandar, fungsi menara pemantau sudah dibangun...

Ice hockey

Team winter sport This article is about the contact team sport played on ice. For the overall family of sports involving sticks and goals, see Hockey. For the sport played on fields and using a hockeyball, see Field hockey. For other uses, see Ice hockey (disambiguation). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Ice hockey – ...

 

趙家驤

追晉陸軍二級上將趙家驤將軍个人资料出生1910年 大清河南省衛輝府汲縣逝世1958年8月23日(1958歲—08—23)（47—48歲） † 中華民國福建省金門縣国籍 中華民國政党 中國國民黨获奖 青天白日勳章（追贈）军事背景效忠 中華民國服役 國民革命軍 中華民國陸軍服役时间1924年－1958年军衔 二級上將 （追晉）部队四十七師指挥東北剿匪總司令部參謀長陸軍�...

 

Bulgarie au Concours Eurovision de la chanson 2022

Bulgarieau Concours Eurovision 2022 Données clés Pays  Bulgarie Chanson Intention Interprète Intelligent Music Project Langue Anglais Sélection nationale Radiodiffuseur BNT Type de sélection Sélection interne Date 25 novembre 2021 (artiste)5 décembre 2021 (chanson) Concours Eurovision de la chanson 2022 Position en demi-finale 16e (29 points, éliminée) 2021 modifier La Bulgarie est l'un des quarante pays participants du Concours Eurovision de la chanson 2022, qui se déroule à...

Statine

Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: leggi le avvertenze. La cascata che porta alla sintesi del colesterolo. Nella parte in alto viene indicato il punto dove le Statine esercitano l'azione inibente. Le statine, o inibitori della HMG-CoA reduttasi, sono farmaci che inibiscono la sintesi del colesterolo endogeno, agendo sull'enzima idrossimetilglutaril-CoA reduttasi, c...

 

Calvin Hill

American football player (born 1947) American football player Calvin HillHill with Cleveland in 1979No. 35Position:Running backPersonal informationBorn: (1947-01-02) January 2, 1947 (age 77)Baltimore, Maryland, U.S.Height:6 ft 4 in (1.93 m)Weight:227 lb (103 kg)Career informationHigh school:Riverdale Country(The Bronx, New York)College:YaleNFL draft:1969 / Round: 1 / Pick: 24Career history Dallas Cowboys (1969–1974) The Hawaiians (1975) Wash...

 

Tawny nurse shark

Species of shark Tawny nurse shark Conservation status Vulnerable  (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Chondrichthyes Subclass: Elasmobranchii Subdivision: Selachimorpha Order: Orectolobiformes Family: Ginglymostomatidae Genus: Nebrius Species: N. ferrugineus Binomial name Nebrius ferrugineus(Lesson, 1831) Range of the tawny nurse shark Synonyms Ginglymostoma muelleri Günther, 1870 Ginglymostoma rueppellii Blee...

Переяслав-Хмельницкое викариатство

Переяслав-Хмельницкое викариатство Церковь Украинская православная церковь Дата основания XI век Управление Главный город Переяслав Иерарх епископ Переяслав-Хмельницкий Дионисий (Пилипчук)[1] Переясла́в-Хмельни́цкое викариа́тство — викариатство Киевской епар�...

 

Chittagong Hill Tracts

Region in southeastern Bangladesh This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Chittagong Hill Tracts – news · newspapers · books · scholar · JSTOR (January 2017) (Learn how and when to remove this message) Chittagong Hill TractsSajek Valley RangamatiGeographyChittagong Hill TractsLocation in Bangladesh L...

 

让·克雷蒂安

非常尊敬的讓·克雷蒂安Jean ChrétienPC OM CC KC  加拿大第20任總理任期1993年11月4日—2003年12月12日君主伊利沙伯二世总督Ray HnatyshynRoméo LeBlancAdrienne Clarkson副职Sheila Copps赫布·格雷John Manley前任金·坎貝爾继任保羅·馬田加拿大自由黨黨魁任期1990年6月23日—2003年11月14日前任約翰·特納继任保羅·馬田 高級政治職位 加拿大官方反對黨領袖任期1990年12月21日—1993年11月...

Denton Wilde Sapte

Denton Wilde Sapte LLPHeadquartersLondon, United KingdomNo. of offices12 (plus 4 associate offices)No. of lawyers610 (2010)[1]No. of employees1,413 (2010)[1]Major practice areasGeneral practiceRevenue£167.5 million (2010)[1]Profit per equity partner£360,000 (2010)[1]Date founded1 February 2000 (London)Company typeLimited liability partnershipDissolved30 September 2010 Denton Wilde Sapte LLP (informally Dentons) was an i...

 

Genetic history of Africa

Not to be confused with Genetic history of the African diaspora. Population structure of African populations in a broad context. ADMIXTURE analysis of 2,194 individuals from 81 populations for 16,420 SNPs reveals both well-established and novel ancestry components in African populations. The genetic history of Africa summarizes the genetic makeup and population history of African populations in Africa, composed of the overall genetic history, including the regional genetic histories of North...

 

IFAF Oceania

Sports governing body IFAF OceaniaMembership 4PresidentMichael RyanWebsitewww.americanfootball.sport IFAF Oceania is the governing body of American football in Oceania. It is a member of the International Federation of American Football. IFAF Oceania replaced the Oceania Federation of American Football (OFAF) in 2012.[1][2] Members  American Samoa  Australia  French Polynesia  Guam  New Caledonia  New Zealand  Papua New Guinea  Tonga Com...

Alcohol in Bangladesh

Alcohol in Bangladesh is regulated and restricted in Bangladesh. Bangladesh has one of the lowest alcohol consumption rates in the world according to a World Bank report published in 2015.[1] History The first distillery was set up in what is today Bangladesh in 1887 by an Englishman named Robert Russell Carew. The company was called Carew & Co (Bangladesh) Ltd and it was nationalised by the government of Bangladesh in 1973.[2] The distillery is part of the Darsana Sugar ...

 

1998 Malaysian motorcycle Grand Prix

  1998 Malaysian Grand PrixRace detailsRace 2 of 14 races in the1998 Grand Prix motorcycle racing seasonDate19 April 1998Official nameMarlboro Malaysian Grand Prix[1]LocationJohor CircuitCoursePermanent racing facility3.860 km (2.398 mi)500 ccPole positionRider Mick Doohan HondaTime 1:28.225 Fastest lapRider Mick Doohan HondaTime 1:29.636 on lap 3 PodiumFirst Mick Doohan HondaSecond Carlos Checa HondaThird Max Biaggi Honda250 ccPole positionRider Jürgen Fuchs Apri...

 

2022 Alaska gubernatorial election

For related races, see 2022 United States gubernatorial elections. 2022 Alaska gubernatorial election ← 2018 November 8, 2022 2026 → Turnout44.40%   Candidate Mike Dunleavy Les Gara Bill Walker Party Republican Democratic Independent Running mate Nancy Dahlstrom Jessica Cook Heidi Drygas Popular vote 132,632 63,851 54,668 Percentage 50.29% 24.21% 20.73% Borough and census area resultsState House district resultsDunleavy:      30�...

Bahnhof Utrecht Centraal

Utrecht Centraal Der Bahnhof nach dem Umbau (2018)Der Bahnhof nach dem Umbau (2018) Daten Lage im Netz Knotenbahnhof Bauform Reiterbahnhof Bahnsteiggleise 16 Abkürzung Ut IBNR 8400621 Eröffnung 18. Dezember 1843 Webadresse NS-Infoseite Architektonische Daten Architekt Benthem Crouwel Lage Stadt/Gemeinde Utrecht Provinz Utrecht Staat Niederlande Koordinaten 52° 5′ 21″ N, 5° 6′ 35″ O52.0891675.109722Koordinaten: 52° 5′ 21″ N, 5°...

 

West Seattle Junction FC

Soccer clubWest Seattle Junction FCFoundedDecember 2023StadiumNino Cantu Southwest Athletics ComplexCapacity4,000OwnersJessica PierceKaitlyn JacksonMarissa VillegasHead CoachErik OmanLeagueUSL League TwoWebsiteClub website Home colors Away colors Current season West Seattle Junction FC is an American soccer club based in the West Seattle neighborhood of Seattle, Washington. The club will play its inaugural season in 2024, as part of the Northwest Division of USL League Two.[1] Juncti...