The 52nd Writers Guild of America Awards, given in 2000, honored the film and television best writers of 1999.

Election - Alexander Payne and Jim Taylor

• The Cider House Rules - John Irving
• The Insider - Michael Mann and Eric Roth
• October Sky - Lewis Colick
• The Talented Mr. Ripley - Anthony Minghella

American Beauty - Alan Ball

• Being John Malkovich - Charlie Kaufman
• Magnolia - Paul Thomas Anderson
• The Sixth Sense - M. Night Shyamalan
• Three Kings - John Ridley and David O. Russell

Merry Christmas, Mrs. Moskowitz - Frasier - Jay Kogen

• The Paper Hat Anniversary - Dharma & Greg - Bill Prady, Eric Zicklin and Chuck Lorre
• The One Where Everybody Finds Out - Friends - Alexa Junge
• Four Women and A Hobo - Sex and The City - Jenny Bicks
• Evolution - Sex and The City - Cindy Chupack

Meadowlands - The Sopranos - Jason Cahill

• The Storm, Part 1 - ER - John Wells
• DWB - Law & Order - René Balcer
• U.S. Male - Oz - Tom Fontana and Bradford Winters

Dash and Lily - Jerrold L. Ludwig

• Freak City - Jane Shepard
• Aldrich Ames: Traitor Within - Michael Burton
• Purgatory - Gordon T. Dawson

• WGA - Previous award winners