Deployed to the new Fifth Air Force in Australia during February 1942, carrying out combat operations over Papua New Guinea in support of Allied ground forces engaging the invading Japanese beginning in April. Engaged in combat throughout the Southwest Pacific Area, being re-equipped with North American B-25 Mitchells in 1943, and long range Consolidated B-24 Liberator heavy bombers in 1944. Fought in the 1944–1945 Philippines Campaign, continuing raids on Japanese forces on Okinawa in 1945.
Squadron demobilized after the Japanese Capitulation, however carried as a Boeing B-29 Superfortress very heavy bomber unit and assigned to Twentieth Air Force in 1946 but not manned or equipped.
Strategic Air Command bombardment operations
Returned to the United States and assigned to Strategic Air Command (SAC) at March Air Force Base in 1948, operating B-29s. Deployed to Okinawa and flew combat operations over North Korea after the breakout of the Korean War in 1950, remaining attached to Far East Air Force Bomber Command until returning to the United States in October. Operated B-29s under SAC until 1953, upgraded to Boeing B-47 Stratojet medium bombers. Engaged in worldwide training exercises throughout the 1950s and early 1960s until the B-47 was phased out of the inventory.
Equipped with Boeing B-52B Stratofortresses for training in 1963; then operational B-52Ds in 1966. Deployed to Western Pacific bases during the Vietnam War and conducted combat operations over Indochina, engaging in Operation Arc Light, Linebacker I and Linebacker II raids over North Vietnam until 1973. Returned to the United States and stood nuclear alert until being inactivated in 1982.
Control of deployed Strategic Air Command aircraft
Hubbard, Gerard (1943). "Aircraft Insignia, Spirit of Youth". The National Geographic Magazine. LXXXIII (6). National Geographic Society: 718–722. Retrieved 1 September 2017. (subscription required for web access)
Brosius, J.W. Jr. (1944). The Marauder:A Book of the 22nd Bomb Group. Sydney, Australia: Halstead Press.
Schroeder, Frederick A. (1985). Ducimus "We Lead" 22nd Bomb Group. Daytona Beach, FL: Hall Publishing Co.
Watkins, Robert A. (2013). Insignia and Aircraft Markings of the U.S. Army Air Force in World War II. Vol. V, Pacific Theater of Operations. Atglen,PA: Shiffer Publishing, Ltd. pp. 72–73. ISBN978-0-7643-4346-9. (Markings of unit B-24, B-25 and B-26 aircraft during World War II)