Singles
2022 Santa Cruz Challenger
Final
Champion	Francisco Cerúndolo
Runner-up	Camilo Ugo Carabelli
Score	6–4, 6–3
Events
Singles Doubles
Santa Cruz Challenger · 2022 →

This was the first edition of the tournament as part of the Legión Sudamericana.^[1]

Francisco Cerúndolo won the title after defeating Camilo Ugo Carabelli 6–4, 6–3 in the final.

	Semifinals							Final
	1	Hugo Dellien	6	4	3
	3	Francisco Cerúndolo	1	6	6
								3	Francisco Cerúndolo	6	6
								8	Camilo Ugo Carabelli	4	3
	8	Camilo Ugo Carabelli	6	6
	Q	Pedro Cachin	3	2

	First round							Second round							Quarterfinals							Semifinals
	1	H Dellien	7	7
		S Rodríguez Taverna	5	5				1	H Dellien	64	77	6
	Q	MF Descotte	77	2	2				D Dutra da Silva	77	63	3
		D Dutra da Silva	63	6	6										1	H Dellien	6	6
	Q	D Hidalgo	3	5											Alt	N Álvarez	1	4
	Alt	N Álvarez	6	7				Alt	N Álvarez	64	6	6
	Q	G Villanueva	5	6	2			5	Z Kolář	77	3	4
	5	Z Kolář	7	4	6																	1	H Dellien	6	4	3
	3	F Cerúndolo	77	2	6																	3	F Cerúndolo	1	6	6
		F Díaz Acosta	64	6	3			3	F Cerúndolo	6	3	77
	Q	JC Prado Ángelo	4	4					TA Tirante	3	6	65
		TA Tirante	6	6											3	F Cerúndolo	6	6
	WC	F Zeballos	5	2												N Moreno de Alboran	3	4
		N Moreno de Alboran	7	6					N Moreno de Alboran	64	6	6
		GA Olivieri	1	1				7	F Mena	77	4	1
	7	F Mena	6	6

	First round							Second round							Quarterfinals							Semifinals
	8	C Ugo Carabelli	6	6
		O Luz	2	4				8	C Ugo Carabelli	6	6
	WC	B Arias	3	2				Q	C Rodríguez	3	3
	Q	C Rodríguez	6	6											8	C Ugo Carabelli	7	6
		D King	4	5											WC	M Dellien	5	3
	WC	M Dellien	6	7				WC	M Dellien	4	6	6
		F Comesaña	4	7	1				F Comesaña	6	4	0
	4	TM Etcheverry	6	5	0r																	8	C Ugo Carabelli	6	6
	6	F Verdasco	6	6																		Q	P Cachin	3	2
		M Pucinelli de Almeida	4	1				6	F Verdasco	6	64	77
		JP Ficovich	6	6					JP Ficovich	3	77	63
	LL	Michel Vernier	1	3											6	F Verdasco	3	1
		G Lama	77	77											Q	P Cachin	6	6
		C Gómez-Herrera	64	63					G Lama	6	3	3
	Q	P Cachin	6	6				Q	P Cachin	4	6	6
	2	A Martin	2	4

• Main draw
• Qualifying draw