Singles
2022 Open Castilla y León
Final
Champion	Hugo Grenier
Runner-up	Constant Lestienne
Score	7–5, 6–3
Events
Singles Doubles
← 2021 · Open Castilla y León · 2023 →

Benjamin Bonzi was the defending champion^[1] but chose not to defend his title.

Hugo Grenier won the title after defeating Constant Lestienne 7–5, 6–3 in the final.

	Semifinals							Final
	5	Ugo Humbert	77	5	2
	4	Hugo Grenier	65	7	6
								4	Hugo Grenier	7	6
								2	Constant Lestienne	5	3
		Michael Geerts	6	5	64
	2	Constant Lestienne	2	7	77

	First round							Second round							Quarterfinals							Semifinals
	1	N Borges	6	6
		M Bašić	3	3				1	N Borges	6	6
	Q	A Kachmazov	0	6	77			Q	A Kachmazov	1	2
	Q	D Istomin	6	4	64										1	N Borges	66	4
		D Masur	6	6											5	U Humbert	78	6
		E Donskoy	4	4					D Masur	3	3
	Q	G Décamps	3	4				5	U Humbert	6	6
	5	U Humbert	6	6																		5	U Humbert	77	5	2
	4	H Grenier	6	6																		4	H Grenier	65	7	6
	WC	A Moro Cañas	4	3				4	H Grenier	6	6
	Q	A Menéndez Maceiras	2	4					N Kuhn	4	4
		N Kuhn	6	6											4	H Grenier	6	6
	Alt	N Álvarez Varona	7	5	1										8	G Barrère	2	2
		A Bellier	5	7	6				A Bellier	4	4
		E Karlovskiy	1	3				8	G Barrère	6	6
	8	G Barrère	6	6

	First round							Second round							Quarterfinals							Semifinals
	7	D Popko	4	4
		M Geerts	6	6					M Geerts	6	6
	SE	D Yevseyev	6	5	6			SE	D Yevseyev	4	3
	WC	D Rincón	2	7	3											M Geerts	6	6
		P Jubb	65	2												Em Nava	4	4
		Em Nava	77	6					Em Nava	710	7
		H Moriya	4	2				3	F Verdasco	68	5
	3	F Verdasco	6	6																			M Geerts	6	5	64
	6	A Çelikbilek	0	2																		2	C Lestienne	2	7	77
	Q	B Lock	6	6				Q	B Lock	78	2	6
		A Kuznetsov	77	1	3			Alt	I Marchenko	66	6	3
	Alt	I Marchenko	64	6	6										Q	B Lock	68	6	3
		A Escoffier	6	6											2	C Lestienne	710	4	6
	WC	Julio César Porras	2	3					A Escoffier	3	3
	Q	A Barroso Campos	6	2	4			2	C Lestienne	6	6
	2	C Lestienne	4	6	6

• Main draw
• Qualifying draw