A total of 14 teams contested the league with a relegation system. Ten teams from the 2020 season, one team relegated from A-Division and three teams promoted from C-Division participated in the league. Saraswati Youth Club was relegated from 2019–20 season, while Church Boys, Birgunj United Club and Samajik Yuwa Club were promoted from the 2021 season.[3]
On 23 March 2022, after losing against Bansbari Club, officials of Shree Bhagawati attacked referee Suman Shrestha.[12] The following day, All Nepal Football Association sanctioned Shree Bhagawati Club coach Sailesh Karmacharya by banning him for three games. The club was also fined NPR 50,000.[8]