Doubles
2022 Knoxville Challenger
Final
Champions	Hunter Reese Tennys Sandgren
Runners-up	Martin Damm Mitchell Krueger
Score	6–7(4–7), 7–6(7–3), [10–5]
Events
Singles Doubles
← 2021 · Knoxville Challenger · 2023 →

Malek Jaziri and Blaž Rola were the defending champions^[1] but chose not to defend their title.

Hunter Reese and Tennys Sandgren won the title after defeating Martin Damm and Mitchell Krueger 6–7^(4–7), 7–6^(7–3), [10–5] in the final.

	First round							Quarterfinals							Semifinals							Final
	1	J Cash H Patten	4	6	[10]
		M Lībietis L Margaroli	6	0	[4]			1	J Cash H Patten	64	6	[10]
		B Shelton D Vale	6	6					B Shelton D Vale	77	2	[3]
		N Álvarez Varona A McHugh	4	4											1	J Cash H Patten	65	4
	4	T Arribagé L Johnson	3	6	[7]											H Reese T Sandgren	77	6
	WC	P Harper Shunsuke Mitsui	6	2	[10]			WC	P Harper S Mitsui	4	5
		H Reese T Sandgren	65	7	[10]				H Reese T Sandgren	6	7
		Abraham Asaba Ezekiel Clark	77	5	[5]																		H Reese T Sandgren	64	77	[10]
		Nathan Ponwith K Smith	67	6	[7]																		M Damm M Krueger	77	63	[5]
		M Damm M Krueger	79	3	[10]				M Damm M Krueger	3	78	[13]
		S Fanselow Lucas Gerch	6	1	[7]			3	A Lawson A Sitak	6	66	[11]
	3	A Lawson A Sitak	3	6	[10]											M Damm M Krueger	6	6
	Alt	Sathi Reddy Chirala VS Prashanth	4	4											2	S Balaji J Nedunchezhiyan	2	3
		A Chandrasekar G Hussey	6	6					A Chandrasekar G Hussey	2	78	[7]
	WC	Jack Vance Tennyson Whiting	63	3				2	S Balaji J Nedunchezhiyan	6	66	[10]
	2	S Balaji J Nedunchezhiyan	77	6

• Main draw