Men's singles
2022 I.ČLTK Prague Open
Final
Champion	Pedro Cachin
Runner-up	Lorenzo Giustino
Score	6–3, 7–6(7–4)
Events
Singles men women Doubles men women
← 2021 · I.ČLTK Prague Open · 2023 →

The men's singles of the 2022 I.ČLTK Prague Open tournament took place on clay in Prague, Czech Republic.

Tallon Griekspoor was the defending champion^[1] but chose not to compete.

Pedro Cachin won the title after defeating Lorenzo Giustino 6–3, 7–6^(7–4) in the final.

	Semifinals							Final
	5	Pedro Cachin	2	6	6
		Geoffrey Blancaneaux	6	2	3
								5	Pedro Cachin	6	77
									Lorenzo Giustino	3	64
		Lorenzo Giustino	77	4	6
		Dimitar Kuzmanov	64	6	2

	First round							Second round							Quarterfinals							Semifinals
	1	A Vukic	1	3
		R Peniston	6	6					R Peniston	1	6	0
	Q	Y Oliel	6	3	2				T Fabbiano	6	4	6
		T Fabbiano	2	6	6											T Fabbiano	3	3
	SE	E Furness	77	3											5	P Cachin	6	6
	PR	S Ofner	63	2r				SE	E Furness	0	3
		D Svrčina	3	1				5	P Cachin	6	6
	5	P Cachin	6	6																		5	P Cachin	2	6	6
	4	V Kopřiva	6	6																			G Blancaneaux	6	2	3
		M Bašić	3	2				4	V Kopřiva	2	4
	LL	M Purcell	4	3				Q	C Tabur	6	6
	Q	C Tabur	6	6											Q	C Tabur	0	1
		V Sachko	3	0r												G Blancaneaux	6	6
	Q	L Rosol	6	0				Q	L Rosol	6	2	63
		G Blancaneaux	6	6					G Blancaneaux	1	6	77
	7	JP Ficovich	4	3

	First round							Second round							Quarterfinals							Semifinals
	8	F Gaio	6	6
	Q	D Michalski	3	1				8	F Gaio	77	2	7
	WC	J Forejtek	7	4	6			WC	J Forejtek	65	6	5
	Q	Lucas Gerch	5	6	3										8	F Gaio	3	6	67
		M Copil	6	62	5											L Giustino	6	3	79
		L Giustino	3	77	7				L Giustino	6	6
	LL	K Uchida	6	4	3			Q	M Donati	1	3
	Q	M Donati	2	6	6																		L Giustino	77	4	6
	6	J de Jong	66	66																			D Kuzmanov	64	6	2
	WC	Martin Krumich	78	78				WC	M Krumich	3	1
	WC	A Paulson	62	66					M Marterer	6	6
		M Marterer	77	78												M Marterer	1	0
		D Kuzmanov	6	6												D Kuzmanov	6	6
	Alt	I Marchenko	1	3					D Kuzmanov	6	7
		R Bonadio	2	4				2	N Borges	1	5
	2	N Borges	6	6

• Main draw
• Qualifying draw