The 174.3-kilometre (108.3 mi) race took place in and around Marseille in southeastern France, starting from the village of Château-Gombert [fr] in the northeastern part of the city and finishing in downtown Marseille next to the Stade Vélodrome. The race course was undulating, with nine marked climbs along the route totalling approximately 3,000 metres (9,800 ft) of elevation. Three of these climbs, the Pas de la Couelle [fr], the Col de l'Espigoulier [fr], and the Route des Crêtes, offered points for the mountains classification for the first three riders to crest their respective summits. The last climb, the Col de la Gineste [fr], crested with 9.5 kilometres (5.9 mi) left before a downhill run-in to the finish line.[2][3]
Nine of the 18 UCI WorldTeams, eight UCI ProTeams, and four UCI Continental teams made up the 21 teams that participated in the race. All but three of these teams entered a full squad of seven riders. Cofidis and Intermarché–Wanty–Gobert Matériaux each entered six riders, while Lotto–Soudal entered five.[6][7] Lotto–Soudal had originally entered six riders as well, but Sylvain Moniquet was forced to withdraw due to a positive COVID-19 test result days before the race.[8]Trek–Segafredo was reduced to six riders with one non-starter, while UAE Team Emirates was reduced to five riders with two non-starters. In total, 140 riders started the race, of which 130 finished.[9]