Singles
2022 Cleveland Open
Final
Champion	Dominic Stricker
Runner-up	Yoshihito Nishioka
Score	7–5, 6–1
Events
Singles Doubles
← 2021 · Cleveland Open · 2023 →

Bjorn Fratangelo was the defending champion^[1] but lost in the first round to Nicola Kuhn.

Dominic Stricker won the title after defeating Yoshihito Nishioka 7–5, 6–1 in the final.

	Semifinals							Final
		Thomas Fabbiano	66	3
	3	Yoshihito Nishioka	78	6
								3	Yoshihito Nishioka	5	1
									Dominic Stricker	7	6
		Michael Mmoh	6	3	62
		Dominic Stricker	3	6	77

	First round							Second round							Quarterfinals							Semifinals
	1	T Sandgren	77	3	77
		C Harrison	65	6	63			1	T Sandgren	6	4	1
		T Fabbiano	7	6					T Fabbiano	3	6	6
		M Krueger	5	3												T Fabbiano	6	6
		C-M Stebe	4	6	6											C-M Stebe	1	3
		M Torpegaard	6	4	2				C-M Stebe	7	3	6
	Q	R Hijikata	64	3				5	J Rodionov	5	6	1
	5	J Rodionov	77	6																			T Fabbiano	66	3
	3	Y Nishioka	6	6																		3	Y Nishioka	78	6
		D Istomin	1	1				3	Y Nishioka	6	1	6
		Y Uchiyama	6	6					Y Uchiyama	4	6	4
	Q	S Fanselow	4	3											3	Y Nishioka	3	6	6
	Q	R Quiroz	4	79	4										WC	W Blumberg	6	4	2
	WC	W Blumberg	6	67	6			WC	W Blumberg	6	3
		J Jung	3	4				7	E Gómez	1	1r
	7	E Gómez	6	6

	First round							Second round							Quarterfinals							Semifinals
	8	J Sock	2	6	6
		B Schnur	6	4	3			8	J Sock	1	1r
		M Mmoh	6	6					M Mmoh	6	2
	WC	A Kovacevic	4	2												M Mmoh	63	6	6
	Q	A Galarneau	77	77											Q	A Galarneau	77	3	0
	Q	U Blanch	65	63				Q	A Galarneau	6	7
		J. J. Wolf	4	1				4	L Broady	1	5
	4	L Broady	6	6																			M Mmoh	6	3	62
	6	E Escobedo	77	6																			D Stricker	3	6	77
	WC	K Smith	63	4				6	E Escobedo	66	7	4
		N Kuhn	710	6					N Kuhn	78	5	0r
		B Fratangelo	68	4											6	E Escobedo	3	64
		G Blancaneaux	4	77	65											D Stricker	6	77
	Q	Em Nava	6	65	77			Q	Em Nava	6	3	4
		D Stricker	6	6					D Stricker	3	6	6
	2	A Seppi	4	4

• Main draw
• Qualifying draw