Singles
2022 Challenger Ciudad de Guayaquil
Final
Champion	Daniel Altmaier
Runner-up	Federico Coria
Score	6–2, 6–4
Events
Singles Doubles
← 2021 · Challenger Ciudad de Guayaquil · 2023 →

Alejandro Tabilo was the defending champion^[1] but chose not to defend his title.

Daniel Altmaier won the title after defeating Federico Coria 6–2, 6–4 in the final.

	Semifinals							Final
	1	Federico Coria	6	2	77
	4	Juan Pablo Varillas	4	6	64
								1	Federico Coria	2	4
								3	Daniel Altmaier	6	6
	3	Daniel Altmaier	77	6
	Q	Marco Cecchinato	64	4

	First round							Second round							Quarterfinals							Semifinals
	1	F Coria	6	78
		F Comesaña	2	66				1	F Coria	3	6	77
	Alt	N Milojević	61	2					F Díaz Acosta	6	1	62
		F Díaz Acosta	77	6											1	F Coria	6	6
	Alt	N Sánchez Izquierdo	1	68												M Pucinelli de Almeida	4	4
		M Pucinelli de Almeida	6	710					M Pucinelli de Almeida	6	6
	Q	Juan Ignacio Galarza	4	63				8	F Meligeni Alves	3	4
	8	F Meligeni Alves	6	77																		1	F Coria	6	2	77
	4	JP Varillas	6	6																		4	JP Varillas	4	6	64
	Q	E Ribeiro	2	1				4	JP Varillas	6	77
	WC	Á Guillén Meza	6	6				WC	A Guillén Meza	1	63
	WC	A Andrade	4	3											4	JP Varillas	6	6
	PR	S Nagal	6	6												N Kicker	1	3
		D Dutra da Silva	2	1				PR	S Nagal	1	6	5
		N Kicker	6	6					N Kicker	6	3	7
	7	S Rodríguez Taverna	1	4

	First round							Second round							Quarterfinals							Semifinals
	6	F Agamenone	7	6
	WC	C March	5	1				6	F Agamenone	2	6	4
		H Casanova	1	77	5				J de Jong	6	4	6
		J de Jong	6	65	7											J de Jong	2	6	3
	Alt	R Quiroz	3	62											3	D Altmaier	6	3	6
		JB Torres	6	77					JB Torres	4	3
	Q	T Seyboth Wild	6	65	2			3	D Altmaier	6	6
	3	D Altmaier	1	77	6																	3	D Altmaier	77	6
	5	JM Cerúndolo	6	6																		Q	M Cecchinato	64	4
		G Melzer	4	2				5	JM Cerúndolo	77	2	4
		TA Tirante	3	65				Q	J Choinski	63	6	6
	Q	J Choinski	6	77											Q	J Choinski	1	3
	Q	M Cecchinato	6	6											Q	M Cecchinato	6	6
	Q	B Bicknell	1	3				Q	M Cecchinato	6	2
	LL	RA Burruchaga	63	7	7			LL	RA Burruchaga	1	0r
	2	TM Etcheverry	77	5	5

• Main draw
• Qualifying draw