Singles
2022 Challenger Città di Lugano
Final
Champion	Luca Nardi
Runner-up	Leandro Riedi
Score	4–6, 6–2, 6–3
Events
Singles Doubles
← 2021 · Challenger Città di Lugano · 2023 →

Dominic Stricker was the defending champion^[1] but lost in the first round to Jurij Rodionov.

Luca Nardi won the title after defeating Leandro Riedi 4–6, 6–2, 6–3 in the final.

	Semifinals							Final
	WC	Leandro Riedi	3	77	77
	4	Pierre-Hugues Herbert	6	63	63
								WC	Leandro Riedi	6	2	3
								Alt	Luca Nardi	4	6	6
		Cedrik-Marcel Stebe	1	1
	Alt	Luca Nardi	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	M Cressy	62	77	4
	WC	L Riedi	77	63	6			WC	L Riedi	6	6
	Q	D Added	6	7				Q	D Added	4	2
		D Masur	4	5											WC	L Riedi	6	77
		M-A Hüsler	6	6												M-A Hüsler	2	64
		A Arnaboldi	4	2					M-A Hüsler	6	6
		T Fabbiano	3	2				5	D Džumhur	3	2
	5	D Džumhur	6	6																		WC	L Riedi	3	77	77
	4	P-H Herbert	77	6																		4	P-H Herbert	6	63	63
		F Horanský	62	4				4	P-H Herbert	6	7
		T van Rijthoven	77	64	7				T van Rijthoven	3	5
	Q	G Brouwer	64	77	5										4	P-H Herbert	2	6	6
	WC	K Feldbausch	1	2											Alt	M Copil	6	4	4
	Q	O Virtanen	6	6				Q	O Virtanen	1	4
	Alt	M Copil	6	2	6			Alt	M Copil	6	6
	6	D Novak	4	6	3

	First round							Second round							Quarterfinals							Semifinals
	8	D Stricker	3	5
		J Rodionov	6	7					J Rodionov	6	6
	Q	Y-s Chung	3	4					Y Sugita	3	0
		Y Sugita	6	6												J Rodionov	1	1
		K Żuk	3	3												C-M Stebe	6	6
		C-M Stebe	6	6					C-M Stebe	4	6	6
		M Bašić	77	6					M Bašić	6	4	3
	3	M Moraing	64	3																			C-M Stebe	1	1
	7	H Grenier	3	4																		Alt	L Nardi	6	6
	Alt	L Nardi	6	6				Alt	L Nardi	6	6
	Q	A Šetkić	77	6				Q	A Šetkić	4	4
	WC	R Bertola	65	4											Alt	L Nardi	4	6	79
		A Müller	3	62											Q	J Kym	6	3	67
	Q	J Kym	6	77				Q	J Kym	3	6	6
		P Kotov	6	6					P Kotov	6	2	1
	2	R Albot	2	3

• Main draw
• Qualifying draw