Singles
2022 Cali Open
Final
Champion	Facundo Mena
Runner-up	Miljan Zekić
Score	6–2, 7–6(7–3)
Events
Singles Doubles
Cali Open · 2023 →

This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.^[1]

Facundo Mena won the title after defeating Miljan Zekić 6–2, 7–6^(7–3) in the final.

	Semifinals							Final
	8	Miljan Zekić	7	6
		Nicolás Mejía	5	4
								8	Miljan Zekić	2	63
								2	Facundo Mena	6	77
		Nicolás Álvarez	66	4
	2	Facundo Mena	78	6

	First round							Second round							Quarterfinals							Semifinals
	1/WC	T Barrios Vera	6	77
	Alt	M Pervolarakis	2	63				1/WC	T Barrios Vera	6	2	1
	Q	RA Burruchaga	6	6				Q	RA Burruchaga	4	6	6
		G Villanueva	1	1											Q	RA Burruchaga	5	2
		P Krstin	6	6											8	M Zekić	7	6
	Q	N Chappell	2	4					P Krstin	6	68	5
		A Kovacevic	6	4	1			8	M Zekić	4	710	7
	8	M Zekić	1	6	6																	8	M Zekić	7	6
	3	JP Ficovich	6	6																			N Mejía	5	4
	WC	A Urrea	3	1				3	JP Ficovich	64	4
	Alt	E Zhu	2	2					N Mejía	77	6
		N Mejía	6	6												N Mejía	6	6
	Q	Matías Zukas	6	6											Q	M Zukas	1	4
		K Smith	4	2				Q	M Zukas	2	6	6
		J Menezes	6	6					J Menezes	6	4	2
	7	G Lama	4	2

	First round							Second round							Quarterfinals							Semifinals
	5	F Comesaña	5	0r
		R Quiroz	7	0					R Quiroz	6	3	3
		N Álvarez	7	77					N Álvarez	4	6	6
		A Menéndez Maceiras	5	63												N Álvarez	64	6	79
	Q	Juan Bautista Otegui	6	79											4	F Meligeni Alves	77	4	67
		V Durasovic	3	67				Q	JB Otegui	6	4	62
		M Jaziri	4	0r				4	F Meligeni Alves	2	6	77
	4	F Meligeni Alves	6	4																			N Álvarez	66	4
	6	G Melzer	6	6																		2	F Mena	78	6
	WC	Mateo Gómez	0	0				6	G Melzer	4	2
	Q	Y-s Chung	6	6				Q	Y-s Chung	6	6
	Q	M Alves	4	0											Q	Y-s Chung	3	7	64
		N Hardt	6	65	3										2	F Mena	6	5	77
		Facundo Juárez	4	77	6				F Juárez	4	0
		G Oliveira	4	4				2	F Mena	6	6
	2	F Mena	6	6

• Main draw
• Qualifying draw