2021 São Paulo Challenger de Tênis
Date	29 November – 5 December
Edition	7th
Surface	Clay
Location	São Paulo, Brazil
Champions
Singles
Juan Pablo Ficovich
Doubles
Nicolás Barrientos / Alejandro Gómez
← 2020 · São Paulo Challenger de Tênis · 2022 →

The 2021 São Paulo Challenger de Tênis was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in São Paulo, Brazil between 29 November and 5 December 2021.

Country	Player	Rank1	Seed
URU	Pablo Cuevas	98	1
BOL	Hugo Dellien	119	2
BRA	Thiago Seyboth Wild	132	3
ARG	Juan Ignacio Londero	144	4
CHI	Nicolás Jarry	160	5
BRA	Felipe Meligeni Alves	180	6
ARG	Nicolás Kicker	236	7
ARG	Pedro Cachin	258	8

• ¹ Rankings as of 22 November 2021.^[1]

The following players received wildcards into the singles main draw:

• Mateus Alves
• Oscar José Gutierrez
• Gustavo Heide

The following players received entry into the singles main draw as alternates:

• Daniel Dutra da Silva
• Alejandro González
• Facundo Juárez
• Gilbert Klier Júnior

The following players received entry from the qualifying draw:

• Luciano Darderi
• Igor Marcondes
• Gonzalo Villanueva
• Matías Zukas

The following player received entry as a lucky loser:

• Alejandro Gómez

• Juan Pablo Ficovich def. Luciano Darderi 6–3, 7–5.

• Nicolás Barrientos / Alejandro Gómez def. Rafael Matos / Felipe Meligeni Alves Walkover.