Singles
2021 Open Città della Disfida
Final
Champion	Giulio Zeppieri
Runner-up	Flavio Cobolli
Score	6–1, 3–6, 6–3
Events
Singles Doubles
← 2019 · Open Città della Disfida · 2022 →

Gianluca Mager was the defending champion^[1] but chose not to defend his title.

Giulio Zeppieri won the title after defeating Flavio Cobolli 6–1, 3–6, 6–3 in the final.

	Semifinals							Final
		Thiago Agustín Tirante	1	6	5
		Flavio Cobolli	6	1	7
									Flavio Cobolli	1	6	3
									Giulio Zeppieri	6	3	6
	8	Tseng Chun-hsin	6	2	3
		Giulio Zeppieri	3	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	A Martin	4	6	6
	WC	J Berrettini	6	2	1			1	A Martin	63	2
		TA Tirante	6	4	6				TA Tirante	77	6
		P Chrysochos	1	6	2											TA Tirante	6	6
	Alt	F Forti	2	2											Q	N Álvarez	2	2
		R Quiroz	6	6					R Quiroz	5	4
	Q	N Álvarez	4	77	7			Q	N Álvarez	7	6
	7	R Bonadio	6	65	5																		TA Tirante	1	6	5
	4	T van Rijthoven	7	6																			F Cobolli	6	1	7
	WC	Emiliano Maggioli	5	4				4	T van Rijthoven	1	2
		P Kotov	2	6	2				F Cobolli	6	6
		F Cobolli	6	4	6											F Cobolli	6	6
	PR	Jeremy Jahn	1r													A Dougaz	3	3
		P Krstin	5						P Krstin	2	2
		A Dougaz	6	6					A Dougaz	6	6
	6	J Draper	3	2

	First round							Second round							Quarterfinals							Semifinals
	8	C-h Tseng	6	0
	Q	R Harrison	1	0r				8	C-h Tseng	5	6	6
	WC	L Nardi	6	6				WC	L Nardi	7	2	4
		M Jaziri	3	1											8	C-h Tseng	6	6
		P Sakamoto	64	63											Q	A Vavassori	4	4
		N Mejía	77	77					N Mejía	3	64
	Q	A Vavassori	6	6				Q	A Vavassori	6	77
	3	J Clarke	3	4																		8	C-h Tseng	6	2	3
	5	M Viola	2	5																			G Zeppieri	3	6	6
	Q	C Rodríguez	6	7				Q	C Rodríguez	4	4
		J Ocleppo	6	6					J Ocleppo	6	6
		J Sels	4	3												J Ocleppo	7	3	2
		G Zeppieri	7	6												G Zeppieri	5	6	6
		T Skatov	5	0					G Zeppieri	6	6
		A Arnaboldi	6	2	5				A Arnaboldi	3	2
	2	JM Cerúndolo	1	6	2r

• Main draw
• Qualifying draw