The 2021 Le Samyn des Dames was the sixth running of the women's Le Samyn, a women's bicycle race in Hainaut, Belgium. It was held on 2 March 2021 over a distance of 94.9 kilometres (59.0 miles) starting in Quaregnon and finishing in Dour. It was rated by the UCI as a 1.2 category race.[1]