Singles
2021 LTP Charleston Pro Tennis II
Final
Champion	Despina Papamichail
Runner-up	Gabriela Cé
Score	1–6, 6–3, 6–3
Events
Singles Doubles
← 2019 · LTP Charleston Pro Tennis · 2022 →

Caroline Dolehide was the defending champion, having won the previous edition in 2019,^[1] however she chose to participate in qualifying for Wimbledon instead.

Despina Papamichail won the title, defeating Gabriela Cé in the final, 1–6, 6–3, 6–3.

	Semifinals							Final
		Sofia Shapatava	3	0
	6	Gabriela Cé	6	6
								6	Gabriela Cé	6	3	3
								2	Despina Papamichail	1	6	6
		Fernanda Contreras	2	2
	2	Despina Papamichail	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	C Perrin	4	63
	Q	Q Gleason	6	77				Q	Q Gleason	6	62	2
		S Shapatava	6	5	6				S Shapatava	0	77	6
		N Hanatani	4	7	1											S Shapatava	2	6	6
	PR	S Xu	3	4												S Chang	6	4	2
		S Chang	6	6					S Chang	6	6
	Q	L Chirico	6	7				Q	L Chirico	2	2
	7	M Zacarías	1	5																			S Shapatava	3	0
	3	H Chang	77	6																		6	G Cé	6	6
	SE	P Stearns	63	4				3	H Chang	6	3	2
		AS Sánchez	6	4	7				AS Sánchez	2	6	6
		ML Carlé	2	6	5											AS Sánchez	4	2
		M Mateas	6	0	713										6	G Cé	6	6
		K Stewart	4	6	611				M Mateas	1	4
	Q	M Sanchez	0	2				6	G Cé	6	6
	6	G Cé	6	6

	First round							Second round							Quarterfinals							Semifinals
	5	K Okamura	3	69
		F Stollár	6	711					F Stollár	0r
	Q	G Topalova	4	2				WC	E Navarro	5
	WC	E Navarro	6	6											WC	E Navarro	4	4
	WC	E Kalieva	0	4												F Contreras	6	6
		F Contreras	6	6					F Contreras	6	6
	WC	E Yu	3	6	3			4	A Parks	3	3
	4	A Parks	6	3	6																		F Contreras	2	2
	8	A Glatch	6	2	7																	2	D Papamichail	6	6
	Q	E Sema	2	6	5			8	A Glatch	6	4	6
	Q	P Hourigan	6	64	1			Q	E Davis	4	6	1
	Q	E Davis	4	77	6										8	A Glatch	6	0	4
	WC	T Ng	3	0											2	D Papamichail	4	6	6
	Q	C Chavatipon	6	6				Q	C Chavatipon	3	3
		A Sutjiadi	6	3	1			2	D Papamichail	6	6
	2	D Papamichail	2	6	6

• Main Draw