Singles
2021 Internazionali di Tennis Città di Perugia
Final
Champion	Tomás Martín Etcheverry
Runner-up	Vitaliy Sachko
Score	7–5, 6–2
Events
Singles Doubles
← 2019 · Internazionali di Tennis Città di Perugia · 2022 →

Federico Delbonis was the defending champion^[1] but chose not to defend his title.

Tomás Martín Etcheverry won the title after defeating Vitaliy Sachko 7–5, 6–2 in the final.

	Semifinals							Final
	1	Salvatore Caruso	5	7	2
	7	Tomás Martín Etcheverry	7	5	6
								7	Tomás Martín Etcheverry	7	6
									Vitaliy Sachko	5	2
		Nino Serdarušić	4	5
		Vitaliy Sachko	6	7

	First round							Second round							Quarterfinals							Semifinals
	1	S Caruso	77	6
	WC	L Vanni	65	4				1	S Caruso	6	6
		A Collarini	6	5	1			WC	F Forti	4	4
	WC	F Forti	4	7	6										1	S Caruso	6	3	6
		F Baldi	3	3											WC	F Cobolli	4	6	3
		N Borges	6	5r					F Baldi	2	63
	WC	F Cobolli	2	7	77			WC	F Cobolli	6	77
	6	D Popko	6	5	63																	1	S Caruso	5	7	2
	3	F Gaio	6	3	62																	7	TM Etcheverry	7	5	6
		D Kuzmanov	2	6	77				D Kuzmanov	4	65
		P Cachin	4	65				Q	N Fatić	6	77
	Q	N Fatić	6	77											Q	N Fatić	3	1
		Y Maden	63	1											7	TM Etcheverry	6	6
		D Stricker	77	6					D Stricker	5	4
		A Arnaboldi	63	2				7	TM Etcheverry	7	6
	7	TM Etcheverry	77	6

	First round							Second round							Quarterfinals							Semifinals
	8	R Olivo	65	7	6
	Q	G Zeppieri	77	5	2			8	R Olivo	5	5
	Q	T Skatov	1	77	6			Q	T Skatov	7	7
		L Giustino	6	65	0										Q	T Skatov	78	4	4
		N Serdarušić	6	6												N Serdarušić	66	6	6
		A Pellegrino	3	3					N Serdarušić	78	6
	Q	F Passaro	6	3	2			4	Zh Zhang	66	4
	4	Zh Zhang	3	6	6																		N Serdarušić	4	5
	5	T Fabbiano	1	6	2																		V Sachko	6	7
		H Rune	6	4	6				H Rune	6	6
		L Klein	6	77					L Klein	4	4
		R Bonadio	1	64												H Rune	3	64
		GM Moroni	2													V Sachko	6	77
		E Furness	0r						GM Moroni	5	6	4
		V Sachko	6	3	6				V Sachko	7	4	6
	2	A Martin	3	6	2

• Main draw
• Qualifying draw