The 2021–22 season was the 55th season in existence of Sivasspor and the club's fifth consecutive season in the top flight of Turkish football. In addition to the domestic league, Sivasspor participated in this season's editions of the Turkish Cup and the inaugural campaign of the UEFA Europa Conference League, having entered in the second qualifying round. The season covered the period from July 2021 to 30 June 2022.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Petrocub Hîncești played their home matches at Zimbru Stadium, Chișinău, instead of their regular stadium Stadionul Municipal, Hîncești, which did not meet UEFA requirements.