The 2021–22 season was the 57th season in the existence of FC Twente and the club's third consecutive season in the top flight of Dutch football. In addition to the domestic league, FC Twente participated in this season's edition of the KNVB Cup.
Source: Eredivisie Rules for classification: Season in progress: 1) Most points won; 2) Less points lost; 3) Goal difference; 4) Goals scored; 5) Alphabetical order; End of season: 1) Points; 2) Goal difference; 3) Goals scored; 4) Head-to-head points; 5) Head-to-head goal difference; 6) Head-to-head away goals scored; 7) Play-off if relevant for deciding champion, relegation or participating in a European league, otherwise by draw. 8) Penalty shoot-out (only after a play-off)[2] (O) Play-off winners Notes:
^Since the winners of the 2021–22 KNVB Cup, PSV, qualified for the Champions League based on their league position, the Europa League play-off berth awarded to the KNVB Cup winners was transferred to the third-placed team Feyenoord, the highest-placed team not qualified for the Champions League. Feyenoord qualified for the Europa League group stage as their opponent in the 2022 UEFA Europa Conference League final, Roma, qualified to the Europa League group stage through domestic performance by finishing sixth in the Serie A.