Incumbent Joaquin Chipeco, Jr. ran in the newly created Lone District of Calamba. Ran for the position are former Euro general Jaime Caringal, former PAGCOR chief Efraim Genuino, former Cabuyao Mayor Isidro Hemedes, Jr., incumbent Board Member Ruth Mariano-Hernandez, Tirso Lavinia, and retired district judge Rosauro Revilla.
2019 Philippine House of Representatives election in Laguna 2nd District.
All municipalities of Laguna, Biñan, Cabuyao, Calamba, San Pablo City, San Pedro City and Santa Rosa City elected a mayor and a vice-mayor this election. The candidates for mayor and vice mayor with the highest number of votes wins the seat; they are voted separately, therefore, they may be of different parties when elected. Below is the list of mayoralty candidates of each city and municipalities per district.
Incumbent Iryne Vierneza ran for Mayor. Her party nominated Art Joseph Francis Mercado, nephew of former 1-UTAK Party list Representative Homer Mercado and son of JAM Transit operator Alita Mercado. His opponent was Delio Hatulan.
Incumbent Angie Yang her term is limited and now is running for councilor her party nominee is incumbent councilor
Justin Colago running this place his opponent is Brgy. Sto Angel Chairman Cesarito Ticzon and Atty/Dr. Emmanuel Loyola
Incumbent Mayor Oscar Rafanan of sought reelection against, former Mayor Jovito Reyes, Alfredo Acaylar, Arturo Capito and incumbent Vice Mayor Alfredo Pajarillo.
In a bid to reclaim his old post, former Mayor Ariel Magcalas is seeking for a comeback trail as Mayor of Santa Cruz, Laguna. His opponents are former Congressman Edgar San Luis and Incumbent Board Member Joseph Kris Benjamin Agarao.