The 2018 CDMX Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Mexico City, Mexico between 9 and 15 April 2018.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
