The 2017–18 season was Plymouth Argyle's first season back in League One since the 2010–11 season, following their promotion from League Two and their 132nd year in existence. Along with competing in League One, the club participated in the FA Cup, EFL Cup and EFL Trophy. The season covers the period from 1 July 2017 to 30 June 2018.
On 5 May 2017, Plymouth Argyle announced Cardiff City will visit during the pre-season schedule.[41] A week later, it was confirmed the club will visit the Netherlands again this summer playing two friendlies whilst abroad while other friendlies were also announced in England.[42] Two more friendlies were revealed on 25 May 2017.[43]
On 16 October 2017, Plymouth Argyle were drawn at home against Grimsby Town in the first round.[44] A second round away trip to Bradford City was confirmed.[45]