Following the previous season's departure of Appalachian State, Georgia Southern, Davidson, and Elon from the league, three new members were added - East Tennessee State, Mercer, and VMI. Both ETSU and VMI had previously competed in the SoCon, as the Buccaneers left for the Atlantic Sun Conference in 2005, while VMI spent eleven years in the Big South. Mercer came from the Atlantic Sun as well. With ten league members, the conference schedule featured a full round-robin with two games against every opponent, totaling eighteen, up from sixteen the previous season.
Wofford, the preseason favorites, cruised through the SoCon regular season with a 16–2 conference record en route to their second straight conference tournament title. Wofford senior guard Karl Cochran was named Player of the Year, while fellow Terrier Lee Skinner was named tournament MVP.