The 2012 Roma Open was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Rome, Italy between 7 and 12 May 2012.
The following players received wildcards into the singles main draw:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
