Singles
2012 Knoxville Challenger
Final
Champion	Michael Russell
Runner-up	Bobby Reynolds
Score	6–3, 6–2
Events
Singles Doubles
← 2011 · Knoxville Challenger · 2013 →

Jesse Levine was the defending champion but was defeated in the First Round by Tennys Sandgren.
Michael Russell won the final 6–3, 6–2 against Bobby Reynolds.

	Semifinals							Final
		Samuel Groth	63	61
	3	Michael Russell	77	77
								3	Michael Russell	6	6
								6	Bobby Reynolds	3	2
	7	Tim Smyczek	4	65
	6	Bobby Reynolds	6	77

	First round							Second round							Quarterfinals							Semifinals
	1	J Levine	64	6	3
		T Sandgren	77	3	6				T Sandgren	77	6
		A Bossel	6	6					A Bossel	62	2
	WC	Jarryd Chaplin	2	4												T Sandgren	62	1
		S Groth	4	6	77											S Groth	77	6
	LL	F Wolmarans	6	1	64				S Groth	77	7
		S-Y Jeong	5	3				5	R Sweeting	63	5
	5	R Sweeting	7	6																			S Groth	63	61
	3	M Russell	6	6																		3	M Russell	77	77
	WC	E Quigley	2	2				3	M Russell	6	6
	Q	D Britton	6	6				Q	D Britton	3	3
	WC	C Harrison	3	4											3	M Russell	4	77	6
		B Klahn	77	4	6										8	D Kudla	6	65	3
		J-P Smith	62	6	3				B Klahn	2	2
		J Sock	3	6	65			8	D Kudla	6	6
	8	D Kudla	6	2	77

	First round							Second round							Quarterfinals							Semifinals
	7	T Smyczek	66	6	77
		A Bogdanovic	78	2	65			7	T Smyczek	7	7
		M Lammer	1	78	4				I van der Merwe	5	5
		I van der Merwe	6	66	6										7	T Smyczek	6	6
		R Williams	63	6	77											R Williams	3	4
	Q	A Krajicek	77	4	64				R Williams	4	7	6
	Q	D King-Turner	2	3				4	M Zverev	6	5	3
	4	M Zverev	6	6																		7	T Smyczek	4	65
	6	B Reynolds	6	6																		6	B Reynolds	6	77
		T-h Yang	2	2				6	B Reynolds	6	6
		C Reix	4	3				PR	J Witten	2	4
	PR	J Witten	6	6											6	B Reynolds	6	6
		A Kuznetsov	7	6												A Kuznetsov	4	3
	WC	Brandon Ficky	5	2					A Kuznetsov	6	6
	Q	L Gregorc	77	5				Q	L Gregorc	4	4
	2	A Bogomolov Jr.	65	1r

• Main Draw
• Qualifying Draw