The 2011-12 LEN Women's Champions' Cup is the ongoing 25th edition of LEN's competition for women's water polo national champion clubs. Thirteen teams from England, France, Germany, Greece, Italy, Russia, Serbia and Spain entered the competition.

Pro Recco defeated Vouliagmeni 8–7 in the final to win the competition for the first time. Kinef Kirishi and Orizzonte Catania also reached the Final Four, with the Russians hosting the stage.^[1] Defending champion CN Sabadell was defeated by Vouliagmeni in the quarter-finals.^[2]

#	Team	Pld	W	D	L	GF	GA	Pt
1	Orizzonte Catania	6	6	0	0	85	45	18
2	Vouliagmeni	6	5	0	1	81	35	15
3	Shturm Ruza	6	4	0	2	67	47	12
4	Liverpool Lizards	6	3	0	3	41	54	9
5	Olympic Nice	6	2	0	4	40	59	6
6	Blau-Weiss Bochum	6	1	0	5	42	68	3
7	Taš-2000 Belgrade (host)	6	0	0	6	27	75	0

#	Team	Pld	W	D	L	GF	GA	Pt
1	Pro Recco	5	5	0	0	74	36	15
2	Kinef Kirishi	5	4	0	1	91	34	12
3	Sabadell	5	3	0	2	52	37	9
4	City of Manchester	5	1	1	3	46	61	4
5	Bayer Uerdingen	5	1	1	3	51	87	4
6	Nancy (host)	5	0	0	5	24	83	0

Team #1	Agg.	Team #2	L #1	L #2
City of Manchester	21–31	Orizzonte Catania	10–16	11–15
Liverpool Lizards	13–30	Pro Recco	7–20	6–10
Sabadell	22–24	Vouliagmeni	14–13	8–11
Shturm Ruza	11–32	Kinef Kirishi	7–14	4–18

• Kirishi, Russia

	Semi-finals				Final
	4 May
	Kinef Kirishi	8
					5 May
	Vouliagmeni	10
					Vouliagmeni	7
	4 May
					Pro Recco	8
	Orizzonte Catania	6
	Pro Recco	14
					Third place
					5 May
					Kinef Kirishi	18
					Orizzonte Catania	12