The 2010 Bucknell Bison football team was an American football team that represented Bucknell University during the 2010 NCAA Division I FCS football season. Bucknell tied for last among Patriot League competitors.

In its first season under head coach Joe Susan, the Bison compiled a 1–10 record.^[1] Josh Eden, Travis Nissley, Jason Vollmar and Marlon Woods were the team captains.^[2]

The team was outscored 310 to 151. Its 1–4 conference record tied with Lafayette for fourth place among the six teams eligible for the Patriot League championship.

Fordham was excluded from the championship; its games did not count in the Patriot League standings, and are shown on the standings tables below the actual last-place teams, Bucknell and Lafayette.^[3]

Bucknell played its home games at Christy Mathewson–Memorial Stadium on the university campus in Lewisburg, Pennsylvania.

Date	Opponent	Site	Result	Attendance	Source
September 4	at Duquesne*	Rooney Field Pittsburgh, PA	L 13–17	2,240	[4]
September 11	at Marist*	Tenney Stadium at Leonidoff Field Poughkeepsie, NY	L 3–14		[1]
September 18	Dartmouth*	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 20–43		[1]
October 2	Cornell^*	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 12–21	7,826	[5]
October 9	Penn*	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 10–31	2,213	[6]
October 16	at Georgetown	Multi-Purpose Field Washington, DC	W 24–21	2,821	[7]
October 23	at Lehigh	Goodman Stadium Bethlehem, PA	L 10–32	7,571	[8]
October 30	Lafayette	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 22–33	3,275	[9]
November 6	Fordham	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 21–33		[1]
November 13	Colgate	Christy Mathewson–Memorial Stadium Lewisburg, PA	L 7–31		[1]
November 20	at Holy Cross	Fitton Field Worcester, MA	L 9–34	4,297	[10]
*Non-conference game Homecoming ^ Parents Weekend