The knockout stage of the 2008 CAF Champions League was played from 5 October to 16 November 2008.^[1]

	Semi-Finals							Final
	1	Enyimba	0	0	0
	4	Al Ahly	0	1	1
								Al Ahly		2	2	4
								Coton Sport FC		0	2	2
	3	Dynamos	0	0	0
	2	Coton Sport FC	1	4	5

The first legs were played on 5 October and the second legs on 17–19 October.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Enyimba	0–1	Al Ahly	0–0	0–1
Dynamos	0–5	Coton Sport FC	0–1	0–4

5 October 2008

15:00 GMT

Enyimba FC	0–0	Al Ahly
	Report

Enyimba International Stadium, Aba

Referee: Daniel Bennett (South Africa)

18 October 2008

18:30 GMT

Al Ahly	1–0	Enyimba FC
Flávio 26'

Cairo International Stadium, Cairo

Referee: Mohammed Ssegonga (Uganda)

5 October 2008

13:00 GMT

Dynamos	0–1	Coton Sport FC
	Report	Kamilou 32'

Rufaro Stadium, Harare

Referee: Koman Coulibaly (Mali)

18 October 2008

14:30 GMT

Coton Sport FC	4–0	Dynamos
Koua 1' Zoua 52' Kamilou 65' Ousmaïla Baba 76'	Report

Stade Omnisport de Garoua, Garoua

Referee: Kacem Bin Nasser (Tunisia)

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Al Ahly	4–2	Coton Sport FC	2–0	2–2

2 November 2008

18:00 GMT

Al Ahly	2–0	Coton Sport FC
Gomaa 4' Flávio 15'	Report

Cairo International Stadium, Cairo

Referee: Jerome Damon (South Africa)

16 November 2008

14:00 GMT

Coton Sport FC	2–2	Al Ahly
Lassina Abdoul Karim 45' Ousmaïla Baba 63'	Report	Ahmed Hassan 38' Shady 89'

Stade Omnisport de Garoua, Garoua

Referee: Djamel Haimoudi (Algeria)

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