28 June – At the first reading, the Chamber of Deputies approves the Treaty establishing a Constitution for Europe ahead of a scheduled referendum on 10 July.
14 October – eBay completes its acquisition of Skype.
14 October – Luxembourg Film Prize for Best Film goes to Heim ins Reich.
25 November – Grand Duke Henri gives grand ducal assent to the law ratifying the Treaty establishing a Constitution for Europe, completing Luxembourg's ratification.