The 2001 National Hockey League All-Star Game took place on February 4, 2001, at Pepsi Center in Denver, home to the Colorado Avalanche. The final score was North America 14, World 12.
The 2000–01 season was highlighted by the return of Mario Lemieux. After 3+1⁄2 years in retirement, Lemieux returned to NHL action and with it came a selection to his ninth NHL All-Star Game. Notching a goal and an assist for the North America All-Stars, Lemieux's All-Star totals climbed to 12 goals and 10 assists for 22 points. He trails only Wayne Gretzky for the All-Star Game's all-time leading scoring title (13–12–25).
Bill Guerin, Tony Amonte and Doug Weight played as an all-American line, combining for 13 points (six goals and seven assists). In his All-Star Game debut, Guerin recorded a hat-trick and added two assists, capturing MVP honors. The North America All-Stars defeated the World All-Stars 14–12, setting a new All-Star Game record for most goals scored by both teams in one game (26).
^1Sean Burke won in a penalty shot tie-breaker with Evgeni Nabokov, both goaltenders posted two-goals against in the Breakaway Relay and the Pass and Score Events.
^2Chris Pronger was voted as a starter, but was not able to play due to injury. Ed Jovanovski was selected as his replacement, while Rob Blake was named as his replacement in the starting lineup. Blake was still a member of the Kings at the time of the All-Star Game; he was traded to the Colorado Avalanche several weeks later on February 21, 2001.