Amateur club Uruguay SC narrowly missed a major second-round upset, losing in overtime to the Tampa Bay Mutiny. Two PDL teams - the Mid Michigan Bucks and the Chicago Sockers - beat MLS teams in the second round, but the quarterfinals were an all-MLS affair. Mid Michigan came closest to duplicating its second-round upset, losing in a shootout to eventual runner-up Miami.
Two referees were used for all games from the second round through the semifinals as part of a FIFA experiment.