The 1999–2000 EHF Women's Champions League was the eighth edition of the modern era of the EHF's premier competition for women's handball clubs, running from 7 October 2000 to 23 May 2001. Krim Ljubljana defeated Viborg HK in the final to become the first Slovenian team to win the competition,^[1] with Budućnost Podgorica and Ferencvárosi TC also reaching the semifinals. Defending champion Hypo Niederösterreich didn't make it past the que group stage.^[2]

Team #1	Agg.	Team #2	1st	2nd
Spartak Kyiv	61–36	Interinvest Mostar	32–21	29–15
Agrotel Plovdiv	35–69	Podravka Koprivnica	17–38	18–31
BGPA Minsk	48–65	Montex Lublin	24–33	24–32
Madeira	53–49	Radnički Beograd	27–24	26–25
Spono Nottwil	52–53	Anagennisi Artas	25–26	27–27
Akva Volgograd	70–35	TMO Ankara	34–19	36–16
VOC Amsterdam	43–44	Egle Vilnius	25–23	18–21
Slovan Duslo Sala	71–36	Siracusa	40–17	31–19

Team #1	Agg.	Team #2	1st	2nd
Leipzig	61–62	Spartak Kyiv	33–27	28–35
Podravka Koprivnica	37–40	Oltchim Rm. Valcea	18–19	19–21
Győri Graboplast	45–44	Montex Lublin	23–19	22–25
Madeira	39–68	Baekkelagets	22–31	17–37
Olimpija Ljubljana	51–52	Anagennisi Artas	31–27	20–25
Akva Volgograd	40–36	Metz	25–20	15–16
Amadeo Tortajada	61–45	Egle Vilnius	31–23	30–22
Slovan Duslo Sala	53–55	Frederiksberg	29–27	24–28

Team	Pld	W	D	L	GF	GA	Pts
Budućnost Podgorica	6	3	2	1	171	149	8
Akva Volgograd	6	3	1	2	148	126	7
Hypo Niederösterreich	6	3	0	3	158	162	6
Frederiksberg	6	1	1	4	132	172	3

Team	Pld	W	D	L	GF	GA	Pts
Herz Ferencvárosi TC	6	4	0	2	175	142	8
Baekkelagets	6	3	2	1	148	147	8
Amadeo Tortajada	6	2	2	2	154	160	6
Lützellinden	6	1	0	5	149	177	2

Team	Pld	W	D	L	GF	GA	Pts
Viborg	6	5	0	1	170	145	10
Larvik	6	4	0	2	152	132	8
Oltchim Rm. Valcea	6	3	0	3	159	150	6
Anagennisi Artas	6	0	0	6	139	193	0

Team	Pld	W	D	L	GF	GA	Pts
Krim Ljubljana	6	3	2	1	153	140	8
Milar Valencia	6	4	0	2	160	159	8
Spartak Kyiv	6	2	0	4	169	171	4
Győri Graboplast	6	1	2	3	156	168	4

Team #1	Agg.	Team #2	1st	2nd
Milar Valencia	48–53	Viborg	25–19	23–34
Akva Volgograd	44–47	Herz Ferencvárosi TC	22–17	22–30
Larvik	41–49	Krim Ljubljana	24–20	17–29
Baekkelagets	44–46	Budućnost Podgorica	24–26	20–20

Team #1	Agg.	Team #2	1st	2nd
Viborg	46–42	Herz Ferencvárosi TC	24–21	22–21
Krim Ljubljana	53–48	Budućnost Podgorica	28–21	25–27

Team #1	Agg.	Team #2	1st	2nd
Viborg	41–47	Krim Ljubljana	22–22	19–25