The 1999 Cork Senior Hurling Championship was the 111th staging of the Cork Senior Hurling Championship since its establishment by the Cork County Board in 1887. The draw for the 1999 opening round fixtures took place on 11 December 1998. The championship began on 5 June 1999 and ended on 31 October 1999. It was the last championship to be played using a straight knock-out format.
On 31 October 1999, Blackrock won the championship following a 3–17 to 0–8 defeat of University College Cork in the final. This was their 30th championship title and their first in 14 championship seasons.
University College Cork's Joe Deane was the championship's top scorer with 3-26.
C McCarthy 1-1, E Fitzpatrick 1-1, B Cunningham 0-4, K Kelleher 0-4, P McSweeney 0-3, I O'Mahony 0-2, M Ryan 0-2, J Griffin 0-1, A Fitzpatrick 0-1, R Curran 0-1.
PJ Carley 1-0, M O'Neill 0-3, B Kearney 0-2, S Doyle 0-1, D Fahy 0-1, N Lahart 0-1, M Molumphy 0-1, E Carey 0-1.