The 1990–91 IHF Women's Cup Winners' Cup was the 15th edition of IHF's competition for European women's handball national cup champions.

Radnički Belgrade defeated 13-times European Cup champion Spartak Kyiv in the final to win its second Cup Winners' Cup, an overall fifth European trophy. This was the last edition where East Germany, one of the competition's powerhouses, was represented due to the reunification of Germany, signed few days after the preliminary round was played. Like in the previous season the ex-East and West German sides, SC Magdeburg and Buxtehuder SV, faced each other, with the latter winning this time.^[1]

	Preliminary round September 23–30, 1990						Round of 12 January 11–20, 1991						Quarterfinals February 17–24, 1991						Semifinals April 7–14, 1991						Final May 5–12, 1991
							SC Magdeburg	27	25	52
							Tiger Palermo	15	20	35
													SC Magdeburg	21	13	34
													Buxtehuder SV	16	23	39
							BSV Weinfelden	16	10	26
	HB Dudelange	2	7	9			Buxtehuder SV	26	24	50
	Buxtehuder SV	41	43	84															Buxtehuder SV	13	23	36
																			Spartak Kyiv	19	25	44
							Spartak Kyiv	25		?
							USM Gagny	22		?
													Spartak Kyiv	21	21	42
													Ştiinţa Bacău	19	19	38
							Ştiinţa Bacău	34	17	51
	Sporting Neerpelt	12	9	21			PSV Eindhoven	17	19	36
	PSV Eindhoven	19	29	48																					Spartak Kyiv	25	15	40
	Ribe HK	18	20	38																					Radnički Belgrade	18	28	46
	Saevsko Vaernamo	23	22	45			Saevsko Vaernamo	17	23	40
							Pogoń Szczecin	18	17	35
													Saevsko Vaernamo	25	25	50
	Colégio de Gaia	21	20	41									Radnički Belgrade	34	38	72
	Estellés Tortajada	37	21	58			Estellés Tortajada	25	27	52
							Radnički Belgrade	29	33	62
																			Radnički Belgrade	30	21	51
																			Debreceni VSC	21	23	44
							Debreceni VSC	32	30	62
							Union Hollabrun	14	23	37
													Debreceni VSC	33	23	66
													IL Gran	28	24	52
							IL Gran	28		?
							DSI Ankara	13		?