Statistics of Primera División de México for the 1980–81 season.
It was contested by 20 teams, and UNAM won the championship.
Atletas Campesinos was promoted from Segunda División.
Unión de Curtidores was relegated to Segunda División.
Atlas won 2-3 on aggregate. Unión de Curtidores was relegated to Segunda División.
UNAM won 4-2 on aggregate.
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