Copa Libertadores 1973 was won by defending champions Independiente of Argentina after defeating Colo Colo of Chile in a third decisive game. The third match which ended 2–1 in extra time was necessary after the previous two leg matches ended in draws. Their fourth consecutive title made Independiente the first team in the tournament's history to win four titles.
The champions and runners-up of each football association were drawn into the same group along with another football association's participating teams. Three clubs from Argentina competed as Independiente was champion of the 1972 Copa Libertadores. They entered the tournament in the Semifinals.