The 1953 Oklahoma A&M Cowboys football team represented Oklahoma Agricultural and Mechanical College (later renamed Oklahoma State University–Stillwater) in the Missouri Valley Conference during the 1953 college football season. In their fourth season under head coach Jennings B. Whitworth, the Cowboys compiled a 7–3 record (3–1 against conference opponents), tied with Detroit for the Missouri Valley championship, and outscored opponents by a combined total of 178 to 149.^[1][2]

On offense, the 1953 team averaged 17.8 points scored, 226.5 rushing yards, and 47.9 passing yards per game.^[3] On defense, the team allowed an average of 14.9 points scored, 164.8 rushing yards and 78.4 passing yards per game.^[4] The team's statistical leaders included Earl Lunsford with 748 rushing yards, Bobby Green with 219 passing yards, and Bob LaRue with 122 receiving yards.^[5]

Four Oklahoma A&M players received first-team All-Missouri Valley Conference honors: end Bob LaRue, tackle Dale Meinert, and backs Bill Bredde, and Earl Lunsford.^[6]

The team played its home games at Lewis Field in Stillwater, Oklahoma.^[7]

Date	Opponent	Site	Result	Attendance	Source
September 19	Hardin–Simmons	Lewis Field Stillwater, OK	W 20–0
September 26	at Arkansas	War Memorial Stadium Little Rock, AR	W 7–6
October 3	Texas Tech	Lewis Field Stillwater, OK	L 13–27	10,000
October 10	Wichita	Lewis Field Stillwater, OK	W 14–7
October 17	at Houston	Rice Stadium Houston, TX	W 14–7	25,000
October 24	at Detroit	University of Detroit Stadium Detroit, MI	L 14–18	14,900	[8]
October 31	Tulsa	Lewis Field Stillwater, OK (rivalry)	W 28–14	18,000
November 7	Wyoming	Lewis Field Stillwater, OK	W 20–14
November 14	at Kansas	Memorial Stadium Lawrence, KS	W 41–14	17,000
November 28	at No. 4 Oklahoma	Oklahoma Memorial Stadium Norman, OK (Bedlam)	L 7–42	50,524
Homecoming Rankings from AP Poll released prior to the game

The 1954 NFL Draft was held on January 28, 1954. The following Cowboys were selected.^[9]