The 1951 West Texas State Buffaloes football team represented West Texas State College—now known as West Texas A&M University—as a member of the Border Conference during the 1951 college football season. Led by fifth-year head coach Frank Kimbrough, the team Buffaloes compiled an overall record of 2–7 with a mark of 1–5 in conference play, placing seventh in the Border Conference.

Date	Time	Opponent	Site	Result	Attendance	Source
September 15		Trinity (TX)*	Amarillo Stadium Amarillo, TX	L 7–19		[1]
September 22		at Texas Tech	Jones Stadium Lubbock, TX	L 7–46	16,000	[2]
September 29		McMurry*	Amarillo Stadium Amarillo, TX	W 28–20		[3]
October 6	9:00 p.m.	at Arizona	Arizona Stadium Tucson, AZ	L 13–28	17,500	[4][5][6]
October 12		North Texas State*	Amarillo Stadium Amarillo, TX	L 14–42	3,000	[7]
October 27	2:30 p.m.	Hardin–Simmons	Buffalo Stadium Canyon, TX	L 6–27	6,000–7,000	[8][9][10]
November 3	9:00 p.m.	at Arizona State	Goodwin Stadium Tempe, AZ	L 0–34	13,000	[11][12]
November 10		at New Mexico A&M	Memorial Stadium Las Cruces, NM	W 50–20	2,000	[13][14][15]
November 24	2:15 p.m.	Texas Western	Amarillo Stadium Amarillo, TX	L 6–13	400	[16][17][18]
*Non-conference game Homecoming All times are in Central time

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