The 1941 Prairie View Panthers football team was an American football team that represented Prairie View Normal and Industrial College—now known as Prairie View A&M University—as a member of the Southwestern Athletic Conference (SWAC) during the 1941 college football season. Led by 11th-year head coach Sam B. Taylor, the Panthers compiled an overall record of 7–1–2 with a mark of 4–0–2 in conference play, winning the SWAC title. At the SWAC winter meeting on December 13, Prairie View's title was forfeited because the Panthers had used an ineligible player, Whiteside. No conference champion is recognized for 1941.^[1]

Date	Time	Opponent	Site	Result	Attendance	Source
October 4		Texas College		T 7–7		[2]
October 13		vs. Wiley	Cotton Bowl Dallas, TX (State Fair Classic)	W 32–7		[3][4]
October 18		Xavier (LA)*	Prairie View, TX	W 21–6	5,000	[5]
October 25		at Arkansas AM&N	Pine Bluff, AR	W 39–14		[6]
November 1		at Tillotson*	Austin, TX	W 33–0		[7]
November 8		Bishop	Prairie View, TX	W 18–7		[8][9]
November 22		Langston	Prairie View, TX	T 0–0		[10]
November 29		at Southern	Baton Rouge, LA	W 19–7		[11]
December 5	7:00 p.m.	vs. Alabama State*	Grove Hill, AL	W 26–20		[12][13][14]
January 1		vs. Kentucky State*	Buffalo Stadium Houston, TX (Prairie View Bowl)	L 13–19		[15]
*Non-conference game Homecoming All times are in Central time