The 1915–16 Missouri Tigers men's basketball team represented University of Missouri in the 1915–16 college basketball season. The team was led by second year head coach Eugene Van Gent. The captain of the team was John Wear.
Missouri finished with a 12–3 record overall and a 9–2 record in the Missouri Valley Intercollegiate Athletic Association. This was good enough for a 2nd-place finish in the regular season conference standings.