Events from the year 1622 in art.

• April – Diego Velázquez moves from Seville to Madrid.

• Artemisia Gentileschi – Portrait of a Condottiero
• Guercino – Et in Arcadia ego
• Frans Hals – Marriage Portrait of Isaac Massa and Beatrix van der Laen
• Gerard van Honthorst – Adoration of the Shepherds
• Pieter Lastman – The Angel and the Prophet Balaam
• Johann Liss – Judith in the Tent of Holofernes
• Guido Reni - St. Francis in Ecstasy
• Dirck van Baburen (some dates approximate)
  • Backgammon Players
  • Christ among the Doctors
  • The Lute Player
  • The Procuress
  • Young Man Singing
• Esaias van de Velde – The Castle Ferry
• Anthony van Dyck – Teresia, Lady Shirley (approximate date)
• Diego Velázquez
  • La mulata (approximate date)
  • Portrait of Don Luis de Góngora

• February 18 - Thomas Regnaudin, French sculptor (died 1706)
• February 27 – Carel Fabritius, Dutch painter who works in Rembrandt's studio in Amsterdam (died 1654)
• May 4 – Juan de Valdés Leal, Spanish Baroque painter (died 1690)
• date unknown
  • Luo Mu, Chinese painter, poet and prose writer (died 1706)
  • Giovanni Maria Morandi, Italian painter of altarpieces (died 1717)
  • Theodore Poulakis, Greek Renaissance painter (died 1692)
• probable
  • Dominique Barrière, French painter and engraver (died 1678)
  • Abraham Lambertsz van den Tempel, Dutch Golden Age painter (died 1672)

• April 15 - Leandro Bassano, Venetian artist and younger brother of Francesco Bassano the Younger (born 1557)
• May 17 - Leonello Spada, Italian Caravaggisto specializing in decorative quadratura painting (born 1576)
• June 3 - Francesco Carracci, Italian painter and engraver (born 1595)
• June 22 - Bernardino Cesari, Italian painter of the late-Mannerist and early Baroque period (born 1565)
• August 10 - Giovanni Battista Viola, Italian painter of landscape canvases (born 1576)
• December 12 - Bartolomeo Manfredi, Italian painter, a leading member of the Caravaggisti (born 1582)
• date unknown
  • Costantini de' Servi, Italian painter (born 1554)
  • Aurelio Lomi, Italian painter of frescoes (born 1556)
  • Vespasiano Strada, Italian painter and engraver (born 1582)
  • Gillis van Valckenborch, Flemish painter (born 1570
• probable - Yi Chong, Korean painter (born 1541)