The year 1613 in science and technology involved some significant events.

• Galileo Galilei publishes Letters on Sunspots, the first major work on the topic.

• Bones, probably of an elephant, are found in France but at first interpreted to belong to a giant human.

• September 29 – The New River (engineered by Sir Hugh Myddelton) is opened to supply London with drinking water from Hertfordshire.^[1]

• March 6 – Stjepan Gradić, Ragusan polymath (died 1683)
• September 25 – Claude Perrault, French architect and physicist (died 1688)

• June 16 – Jakob Christmann, German orientalist and astronomer (born 1554)
• July 2 – Bartholomaeus Pitiscus, German trigonometrist (born 1561)
• August 25 – David Gans, German Jewish mathematician and astronomer (born 1541)
• Mathew Baker, English shipwright (born 1530)
• Johann Bauhin, Swiss physician and botanist (born 1541)
• Jacques Guillemeau, French surgeon (born 1550)