The enzyme (S)-methylmalonyl-CoA hydrolase (EC 3.1.2.17) catalyzes the reaction

(S)-methylmalonyl-CoA + H₂O ${\displaystyle \rightleftharpoons }$ methylmalonate + CoA

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-methylmalonyl-CoA hydrolase. This enzyme is also called D-methylmalonyl-coenzyme A hydrolase. This enzyme participates in propanoate metabolism.

• Kovachy RJ, Copley SD, Allen RH (1983). "Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase". J. Biol. Chem. 258 (18): 11415–21. PMID 6885824.