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(a) SCF contains three core subunits—the RING protein Rbx1, the cullin Cul1, and Skp1. Rbx1 binds the E2–ubiquitin conjugate. The target protein binds to an F-box protein that is bound to the enzyme core via interactions with the Skp1 subunit. After binding of a target protein to the F-box protein, the ubiquitin is transferred from E2 and attached via a peptide bond to a lysine side chain in the target protein. (b) A composite model structure for human SCF derived from X-ray structures of...

Bagian dari seriGereja Katolik menurut negara Afrika Afrika Selatan Afrika Tengah Aljazair Angola Benin Botswana Burkina Faso Burundi Chad Eritrea Eswatini Etiopia Gabon Gambia Ghana Guinea Guinea-Bissau Guinea Khatulistiwa Jibuti Kamerun Kenya Komoro Lesotho Liberia Libya Madagaskar Malawi Mali Maroko Mauritania Mauritius Mesir Mozambik Namibia Niger Nigeria Pantai Gading Republik Demokratik Kongo Republik Kongo Rwanda Sao Tome dan Principe Senegal Seychelles Sierra Leone Somalia Somaliland ...

Andi Abdul Muis Prof. Dr. Andi Abdul Muis (Pulau Kalukuang, Kabupaten Pangkep, 4 Desember 1929–Makassar, 6 Agustus 2005) adalah seorang pakar ilmu komunikasi dan pejuang kebebasan pers Indonesia. Setelah lulus SMA pada tahun 1952, Muis masuk Fakultas Hukum dan Ilmu Pengetahuan Kemasyarakatan Universitas Indonesia. Karena kondisi keuangan yang tak memungkinkan, ia kembali ke Makassar dan bergabung dengan Permesta (Perjuangan Rakyat Semesta). Pada tahun 1956–1959, ia menjabat sebagai Pemimp...

American professional soccer player (born 1999) Yazmeen Ryan Ryan with Gotham in 2023Personal informationFull name Yazmeen Ann Ryan[1]Date of birth (1999-02-25) February 25, 1999 (age 25)Height 5 ft 6 in (1.68 m)Position(s) MidfielderTeam informationCurrent team NJ/NY Gotham FCNumber 18Youth career Norman CelticCollege careerYears Team Apps (Gls)2017–2021 TCU Horned Frogs 68 (19)Senior career*Years Team Apps (Gls)2017–2019 Oklahoma City 2021–2022 Portland Tho...

Questa voce sull'argomento araldica è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Il rosso è uno smalto araldico di colore rosso. Nella rappresentazione monocromatica è simboleggiato da linee parallele verticali. A sinistra: Rosso, a destra: rappresentazione monocromatica Di rosso pieno Rosso nella rappresentazione monocromatica D'argento, alla croce di rosso Di rosso, alla decusse di rosso Di ross...

Defensive strategy in basketball Match-up zone defense is a type of defense used in the game of basketball. It is commonly referred to as a combination defense, as it combines certain aspects of man-to-man defense and zone defense. College head coaches Jim Boeheim and John Chaney were advocates of the match-up zone defense.[1] Characteristics With the match-up zone defense, the on-ball defender will play tight as if he was playing man-to-man. At the same time, the zone away from the b...

Pour les articles homonymes, voir Fustel et Coulanges. Numa Denis Fustel de CoulangesPortrait photographique par Eugène Pirou.FonctionDirecteurÉcole normale supérieure1880-1883Ernest BersotGeorges PerrotBiographieNaissance 18 mars 1830Ancien 2e arrondissement de ParisDécès 12 septembre 1889 (à 59 ans)MassySépulture MassyNationalité françaiseFormation École normale supérieure (1850-1853)Faculté des lettres de Paris (doctorat) (jusqu'en 1858)Lycée CharlemagneActivités Histor...

First Tarnovo uprisingDate1598LocationRegion of Bulgaria, Ottoman EmpireResult Ottoman victory Rebellion SuppressedBelligerents Bulgarian rebels Ottoman EmpireCommanders and leaders Theodore BalinaIvan Shishman IIDionysus RallisPavel ĐorđićSorkočević brothers UnknownStrength over 12,000 UnknownCasualties and losses Unknown Unknown vteBulgarian–Ottoman conflicts Bulgarian–Ottoman wars (1345–1396) Ihtiman Samokov Chernomen Sofia Tarnovo (1393) Uprisings in Ottoman Bulgaria (1396–18...

1918 film Wild WomenPoster for filmDirected byJohn FordWritten byHarry CareyJohn FordGeorge HivelyProduced byHarry CareyStarringHarry CareyCinematographyJohn W. BrownBen F. ReynoldsDistributed byUniversal Film Manufacturing CompanyRelease date February 25, 1918 (1918-02-25) Running time50 minutesCountryUnited StatesLanguagesSilentEnglish intertitles Wild Women is a 1918 American silent Western comedy film directed by John Ford and featuring Harry Carey. The film is considered t...

周處除三害The Pig, The Snake and The Pigeon正式版海報基本资料导演黃精甫监制李烈黃江豐動作指導洪昰顥编剧黃精甫主演阮經天袁富華陳以文王淨李李仁謝瓊煖配乐盧律銘林孝親林思妤保卜摄影王金城剪辑黃精甫林雍益制片商一種態度電影股份有限公司片长134分鐘产地 臺灣语言國語粵語台語上映及发行上映日期 2023年10月6日 (2023-10-06)（台灣） 2023年11月2日 (2023-11-02)（香�...

هذه مقالة غير مراجعة. ينبغي أن يزال هذا القالب بعد أن يراجعها محرر؛ إذا لزم الأمر فيجب أن توسم المقالة بقوالب الصيانة المناسبة. يمكن أيضاً تقديم طلب لمراجعة المقالة في الصفحة المخصصة لذلك. (يناير 2022) مفتش أسلحة تابع للأمم المتحدة في العراق عام 2002. بدأ صدام حسين (1937-2006) برنامجً...

British military radio transmitter ASPI 4 and DWS logos in one of the remaining buildings Aspidistra was a British medium-wave radio transmitter used for black propaganda and military deception purposes against Nazi Germany during World War II. At times in its history it was the most powerful broadcast transmitter in the world. Its name – after the popular foliage houseplant – was inspired by the 1938 comic song The Biggest Aspidistra in the World, best known as sung by Gracie Fields. The...

Arms of the office of Arch-Treasurer of the Holy Roman Empire, showing the imperial crown Arms of the electorate of Brunswick-Lüneburg, with the Arch-Treasurer's crown at centre. An Arch-Treasurer (German: Erzschatzmeister, Latin: Archithesaurarius) is a chief treasurer, specifically the great treasurer of the Holy Roman Empire. The title of Arch-Treasurer was only ceremonially significant, as it was only used in the coronation of Emperors.[1] History During the 30 Years' War, Freder...

Pour les articles homonymes, voir Gravel. Mike Gravel Mike Gravel en 2007. Fonctions Sénateur des États-Unispour l'Alaska 3 janvier 1969 – 3 janvier 1981 (12 ans) Prédécesseur Ernest Gruening Successeur Frank Murkowski Biographie Date de naissance 13 mai 1930 Lieu de naissance Springfield (Massachusetts, États-Unis) Date de décès 26 juin 2021 (à 91 ans) Lieu de décès Seaside (Californie) Parti politique Parti démocrate (avant 2008 et depuis 2010)Parti libertarien (2008...

Raccordo autostradale 13 Sistiana-PadricianoLocalizzazioneStato Italia Regioni Friuli-Venezia Giulia Province Trieste DatiClassificazioneAutostrada InizioSistiana FinePadriciano Lunghezza21,411 km GestoreAnas PercorsoPrincipali intersezioniNSA50, RA13, SS202dir Strade europee Manuale Il raccordo autostradale 13 Sistiana-Padriciano, siglato come RA13, collega l'autostrada A4 con l'autostrada Sistiana-Rabuiese. La strada è parte della cosiddetta Grande Viabilità Triestina. Indi...

彼女と彼女の猫 ジャンル 日常 映画：彼女と彼女の猫Their standing points 監督 新海誠 制作 新海誠 封切日 1999年 上映時間 4分46秒（フルバージョン）1分30秒（ダイジェスト版） 漫画 原作・原案など 新海誠 作画 山口つばさ 出版社 講談社 掲載誌 月刊アフタヌーン レーベル アフタヌーンKC 発表号 2016年4月号 - 7月号 巻数 全1巻 アニメ：彼女と彼女の猫-Everything Flows- 原作 新�...

Medical conditionNeuroleptic malignant syndromeHaloperidol, a known cause of NMSSpecialtyCritical care medicine, neurology, psychiatrySymptomsHigh fever, confusion, rigid muscles, variable blood pressure, sweating[1]ComplicationsRhabdomyolysis, high blood potassium, kidney failure, seizures[1][2]Usual onsetWithin a few weeks or days[3]CausesAntipsychotic medication[1]Risk factorsDehydration, agitation, catatonia[4]Diagnostic methodBased on sympt...

You can help expand this article with text translated from the corresponding article in Chinese. (February 2020) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not translate text that appears unreliable or l...

Part of a series onClassical mechanics F = d p d t {\displaystyle {\textbf {F}}={\frac {d\mathbf {p} }{dt}}} Second law of motion History Timeline Textbooks Branches Applied Celestial Continuum Dynamics Kinematics Kinetics Statics Statistical mechanics Fundamentals Acceleration Angular momentum Couple D'Alembert's principle Energy kinetic potential Force Frame of reference Inertial frame of reference Impulse Inertia / Moment of inertia Mass Mechanical power Mechanical work Moment Mo...

2004 Conservative Party of Canada leadership election ← 2003 (PC) 2002 (CA) March 20, 2004 2017 →   Candidate Stephen Harper Belinda Stronach Tony Clement Popular vote 67,143 22,286 7,968 Percentage 68.9% 22.9% 8.2% Points 17,296 10,613 2,887 Percentage 56.2% 34.5% 9.4% Results by Canadian electoral district Leader before election John Lynch-Staunton (interim) Elected Leader Stephen Harper 2004 Conservative leadership electionConventionMetro Toronto Convention...