Sulbaktam

Sulbaktam
Nama sistematis (IUPAC)
(2S,5R)-3,3-Dimetil-7-okso-4-tia-1-azabisiklo[3.2.0]heptana-2-asam karboksilat 4,4-dioksida
Data klinis
AHFS/Drugs.com International Drug Names
MedlinePlus a693021
Kat. kehamilan ?
Status hukum POM (UK)
Rute Intravena, intramuskular
Data farmakokinetik
Ikatan protein 29%
Waktu paruh 0,65–1,20 jam
Ekskresi Terutama ginjal (41–66% dalam 8 jam)
Pengenal
Nomor CAS 68373-14-8 YaY
Kode ATC J01CG01
PubChem CID 130313
ChemSpider 115306 YaY
UNII S4TF6I2330 YaY
KEGG D08533 YaY
ChEBI CHEBI:9321 YaY
ChEMBL CHEMBL403 YaY
Data kimia
Rumus C8H11NO5S 
SMILES eMolecules & PubChem

  • InChI=1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1 YaY
    Key:FKENQMMABCRJMK-RITPCOANSA-N YaY

Data fisik
Titik lebur 148–151 °C (298–304 °F)

Sulbaktam adalah inhibitor beta-laktamase. Obat ini diberikan dalam kombinasi dengan antibiotik beta-laktam untuk menghambat β-laktamase, enzim yang diproduksi oleh bakteri yang menghancurkan antibiotik.[1] Obat ini dipatenkan pada tahun 1977 dan disetujui untuk penggunaan medis pada tahun 1986.[2]

Mekanisme kerja

Sulbaktam terutama digunakan sebagai penghambat bunuh diri β-laktamase, melindungi beta-laktam yang lebih kuat seperti ampisilin.[3] Sulbaktam sendiri mengandung cincin beta-laktam, dan memiliki aktivitas antibakteri yang lemah dengan menghambat protein pengikat penisilin (PBP) 1 dan 3, tetapi tidak menghambat 2.[4]

Kombinasi

Kombinasi ampisilin/sulbaktam tersedia di Amerika Serikat.[5]

Kombinasi sefoperazon/sulbaktam (Sulperazon) tersedia di banyak negara.[6]

Kombinasi sulbaktam/durlobaktam yang dikemas bersama telah disetujui untuk penggunaan medis di Amerika Serikat pada Mei 2023.[7]

Referensi

  1. ^ Totir MA, Helfand MS, Carey MP, Sheri A, Buynak JD, Bonomo RA, Carey PR (August 2007). "Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase". Biochemistry. 46 (31): 8980–8987. doi:10.1021/bi7006146. PMC 2596720 alt=Dapat diakses gratis. PMID 17630699. 
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (dalam bahasa Inggris). John Wiley & Sons. hlm. 492. ISBN 9783527607495. 
  3. ^ Crass RL, Pai MP (February 2019). "Pharmacokinetics and Pharmacodynamics of β-Lactamase Inhibitors". Pharmacotherapy. 39 (2): 182–195. doi:10.1002/phar.2210. PMID 30589457. 
  4. ^ Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, et al. (March 2015). "Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy. 59 (3): 1680–1689. doi:10.1128/AAC.04808-14. PMC 4325763 alt=Dapat diakses gratis. PMID 25561334. 
  5. ^ "Unasyn- ampicillin sodium and sulbactam sodium injection, powder, for solution". DailyMed. U.S. National Library of Medicine. 29 March 2023. Diakses tanggal 25 May 2023. 
  6. ^ "Sulperazon". drugs.com. 
  7. ^ "FDA Approves New Treatment for Pneumonia Caused by Certain Difficult-to-Treat Bacteria". U.S. Food and Drug Administration (Siaran pers). 24 May 2023. Diakses tanggal 24 May 2023. 

Bacaan lebih lanjut

  • Singh GS (January 2004). "Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam". Mini Reviews in Medicinal Chemistry. 4 (1): 93–109. doi:10.2174/1389557043487547. PMID 14754446. 

Read other articles:

Fratellanza Sportiva Sestrese Calcio 1919

F.S. Sestrese Calcio 1919Calcio Verdestellati Segni distintivi Uniformi di gara Casa Trasferta Colori sociali Verde stellato Dati societari Città Genova Nazione  Italia Confederazione UEFA Federazione FIGC Campionato Eccellenza Fondazione 1919 Rifondazione1961 Presidente Sebastiano Sciortino Allenatore Cristiano Rossetti Stadio Giuseppe Piccardo di Borzoli(400 posti) Sito web www.sestresecalcio.com Palmarès Dati aggiornati al 29 ottobre 2020Si invita a seguire il modello di voce L...

 

 

California Straight Ahead (film 1925)

California Straight AheadPoster rilis teatrikalSutradaraHarry A. PollardDitulis olehDwinelle BenthallByron MorganHarry A. PollardBeatrice VanPemeranReginald DennyGertrude OlmsteadTom WilsonSinematograferVirgil MillerGilbert WarrentonPenyuntingDaniel MandellEdward SchroederPerusahaanproduksiUniversal PicturesDistributorUniversal PicturesTanggal rilis 13 September 1925 (1925-09-13) Durasi80 menitNegaraAmerika SerikatBahasaBisu (intertitel Inggris) California Straight Ahead adalah sebuah fi...

 

 

Dusty Wathan

American baseball player and coach (born 1973) Baseball player Dusty WathanWathan with the Phillies in 2019Philadelphia Phillies – No. 62Catcher/ CoachBorn: (1973-08-22) August 22, 1973 (age 50)Jacksonville, Florida, U.S.Batted: RightThrew: RightMLB debutSeptember 24, 2002, for the Kansas City RoyalsLast MLB appearanceSeptember 29, 2002, for the Kansas City RoyalsMLB statisticsBatting average.600Home runs0Runs batted in1 TeamsAs player Kansas City Royals (...

The Rite (1969 film)

1969 Swedish filmThe RitePromotional posterDirected byIngmar BergmanWritten byIngmar BergmanProduced byLars-Owe CarlbergStarringIngmar BergmanGunnar BjörnstrandAnders EkErik HellIngrid ThulinCinematographySven NykvistRelease date25 March 1969Running time72 minutesCountrySwedenLanguageSwedish The Rite (Swedish: Riten) is a 1969 Swedish drama film written and directed by Ingmar Bergman. It premiered on Swedish television on 25 March 1969.[1] Actors Thea (Ingrid Thulin), Sebastian (And...

 

 

Teluk Palabuhanratu

Artikel ini bukan mengenai taman bumi di Jawa Barat, Indonesia Untuk taman bumi, lihat Taman Bumi Ciletuh-Palabuhanratu. Untuk kegunaan lain, lihat Palabuhanratu (disambiguasi). Lihat pula: Pantai Palabuhanratu Teluk Palabuhanratu Lokasi Teluk Palabuhanratu di Kabupaten SukabumiTampilkan peta Kabupaten SukabumiTeluk Palabuhanratu (Jawa Barat)Tampilkan peta Jawa BaratTeluk Palabuhanratu (Jawa)Tampilkan peta JawaTeluk Palabuhanratu (Indonesia)Tampilkan peta Indonesia Informasi Lokasi Kabupaten ...

 

 

Law for Protection of the Nation

Bulgarian anti-Jewish law (1941–1944) Part of a series onDiscrimination Forms Institutional Structural Attributes Age Caste Class Dialect Disability Genetic Hair texture Height Language Looks Mental disorder Race / Ethnicity Skin color Scientific racism Rank Sex Sexual orientation Species Size Viewpoint Social Arophobia Acephobia Adultism Anti-albinism Anti-autism Anti-homelessness Anti-drug addicts Anti-intellectualism Anti-intersex Anti-left handedness Anti-Masonry Antisemitism A...

Pipreola

Genus of birds Fruiteater redirects here. For fruit-eating animals in general, see Frugivore. Pipreola Black-chested fruiteater (Pipreola lubomirskii) Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Passeriformes Family: Cotingidae Genus: PipreolaSwainson, 1838 Type species Pipreola chlorolepidota (fiery-throated fruiteater)Swainson, 1838 Pipreola is a genus of bird in the family Cotingidae. Together with Ampelioides tschudii, they are collect...

 

 

Giulia Melidoni

Questa voce sull'argomento attori italiani è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Complesso di prosa di Radio Napoli. Giulia Melidoni è la seconda da destra. Giulia Melidoni (Napoli, 23 gennaio 1913 – Roma, 23 gennaio 1966) è stata un'attrice italiana. Indice 1 Biografia 2 Discografia 3 Filmografia 4 Teatro 5 Note 6 Bibliografia 7 Collegamenti esterni Biografia Attrice partenopea, esordì ...

 

 

Libri (Apple)

Disambiguazione – iBooks rimanda qui. Se stai cercando il laptop di casa Apple, vedi iBook. LibrisoftwareLogoLibri su macOS Big SurLibri su macOS Big Sur GenereSoftware per la lettura di ebook SviluppatoreApple Inc. Data prima versione2 aprile 2010 Ultima versioneiOS: 4.11 macOS: 1.16 (24 settembre 2018) Sistema operativoiOSmacOS LinguaggioObjective C LicenzaProprietario(licenza non libera) Sito webwww.apple.com/it Modifica dati su Wikidata · Manuale Libri, in ...

Мидийцы

Эту страницу предлагается переименовать в «Мидяне».Пояснение причин и обсуждение — на странице Википедия:К переименованию/8 июня 2023. Пожалуйста, основывайте свои аргументы на правилах именования статей. Не удаляйте шаблон до подведения итога обсуждения. Переименова�...

 

 

Ilario Spolverini

Il duca di Parma Antonio Farnese, 1720 Ilario Giacinto Mercanti detto lo Spolverini (Parma, 13 gennaio 1657 – Parma, 4 agosto 1734) è stato un pittore italiano. Indice 1 Biografia 2 Opere 3 Note 4 Bibliografia 5 Voci correlate 6 Altri progetti 7 Collegamenti esterni Biografia Fu il migliore allievo di Francesco Monti e «non altrimenti che il suo maestro, si acquistò nome dipingendo battaglie né so se per esagerazione o per verità solea dirsi che i soldati del Monti minacciavano e quei ...

 

 

WSHO

Radio station in New Orleans, LouisianaWSHONew Orleans, LouisianaBroadcast areaNew OrleansFrequency800 kHzBrandingSonshine 800ProgrammingFormatChristian radioAffiliationsSalem CommunicationsOwnershipOwnerShadowlands Communications, L.L.C.Technical informationFacility ID9235ClassBPower1,000 watts day233 watts nightTransmitter coordinates29°50′42.00″N 90°6′39.00″W / 29.8450000°N 90.1108333°W / 29.8450000; -90.1108333LinksWebsiteOfficial website WSHO (800 AM) ...

Anna Huntington Stanley

Anna Huntington StanleyLahir(1864-04-20)20 April 1864Yellow Springs, Ohio, Amerika SerikatMeninggal25 Februari 1907(1907-02-25) (umur 42)Chester, PennsylvaniaGerakan politikAmerican ImpressionismAnna Huntington Stanley (20 April 1864 – 25 Februari 1907) adalah seorang Artis Impresionis Amerika. Ia lahir pada 20 April 1864 di Yellow Springs, Ohio dari pasangan Anna Maria Wright dan Jenderal David Sloan Stanley, Angkatan Darat AS. Dia meninggal pada tahun 1907.[1] ...

 

 

Bourse d'Amsterdam

Bourse d'AmsterdamPrésentationType Bâtiment de salle de concert, théâtre, lieu pour des événements (d)Fondation 1903, 1884Style Botten (en)Architecte Hendrik Petrus BerlageMatériau briqueConstruction 1898-1903Ouverture 27 mai 1903Propriétaire AmsterdamPatrimonialité Rijksmonument (1970)Site web www.beursvanberlage.nlLocalisationAdresse 1 place de la Bourse 1012JW Amsterdam Pays-BasCoordonnées 52° 22′ 30″ N, 4° 53′ 47″ Emodifier - mod...

 

 

Community First Champion Center

Arena located in Grand Chute, Wisconsin Community First Champion CenterLogoMain entrance gateCommunity First Champion CenterLocation in WisconsinShow map of WisconsinCommunity First Champion CenterCommunity First Champion Center (the United States)Show map of the United StatesFull nameCommunity First Champion Center Fox CitiesAddress2200 North McCarthy RoadGrand Chute, Wisconsin, United StatesCoordinates44°16′57″N 88°28′51″W / 44.28250°N 88.48083°W / 44.282...

Rum ration

Daily amount of rum given to Royal Navy sailors; abolished in 1970 A sailor on board HMS York measures out tots of rum for the ship's company, in preparation for the Royal Navy tradition Splice the Mainbrace The rum ration (also called the tot) was a daily amount of rum given to sailors on Royal Navy ships. It was abolished in 1970 after concerns that the intake of strong alcohol would lead to unsteady hands when working machinery. Tradition The rum ration, or tot, from 1866 to 1970 con...

 

 

Alex de Angelis

Alex de AngelisDe Angelis di Grand Prix Australia 2010KebangsaanSan MarinoLahir26 Februari 1984 (umur 40)Rimini, ItaliaTim saat iniOcto Pramac RacingNo. motor5Situs webalexdeangelis.com Catatan statistik Karier Kejuaraan Dunia MotoGP Tahun aktif2008–2010, 2013–2015 PabrikanHonda, Ducati, Forward Yamaha, ART Juara dunia0Klasemen 201528th (2 poin) Start Menang Podium Pole F. lap Poin 61 0 1 0 0 206 Karier Kejuaraan Dunia Moto2Tahun aktif2010–2014, 2017 PabrikanForce GP210, Motobi, Su...

 

 

Spazio Oberdan

Spazio Oberdan UbicazioneStato Italia LocalitàMilano Coordinate45°28′31.33″N 9°12′14.26″E45°28′31.33″N, 9°12′14.26″E CaratteristicheTipoarte Istituzione1999 Sito web Modifica dati su Wikidata · Manuale Lo Spazio Oberdan è stato uno spazio dedicato alla cultura creato e gestito dall'assessorato alla cultura dalla provincia di Milano. Indice 1 Descrizione 2 La Sala Alda Merini 3 Le mostre 4 Note 5 Collegamenti esterni Descrizione Concepito dall'architetta Gae Au...

1909–10 Princeton Tigers men's ice hockey season

College ice hockey season 1909–10 Princeton Tigers men's ice hockey seasonIntercollegiate ChampionIntercollegiate Hockey Association, Champion Conference1st IHAHome iceLake CarnegieRecordOverall7–3–0Conference5–0–0Road1–0–0Neutral6–3–0Coaches and captainsCaptain(s)Clarence Peacock Jr.Princeton Tigers men's ice hockey seasons« 1908–09 1910–11 » The 1909–10 Princeton Tigers men's ice hockey season was the 11th season of play for the program. Season Princet...

 

 

Common Era

Modern calendar era BCE redirects here. For other uses, see BCE (disambiguation). Common Era (CE) and Before the Common Era (BCE) are year notations for the Gregorian calendar (and its predecessor, the Julian calendar), the world's most widely used calendar era. Common Era and Before the Common Era are alternatives to the original Anno Domini (AD) and Before Christ (BC) notations used for the same calendar era. The two notation systems are numerically equivalent: 2024 CE and AD 2024 each desc...