Statin

Statin
Kelas obat-obatan
Lovastatin
Lovastatin, komponen yang diisolasi dari Aspergillus terreus, adalah statin pertama yang dipasarkan.
Pengenal kelas
Penggunaanhiperkolesterolemia
Kode ATCC10AA
Target biologisHMG-CoA reduktase
Data klinis
Drugs.comDrug Classes
Pranala luar
MeSHD019161
Dalam Wikidata

Statin adalah golongan obat yang digunakan untuk menurunkan kadar lipoprotein densitas rendah atau low density lipoprotein (LDL). [1]

Statin bekerja secara kompetitif dengan koenzim 3-hidroksi-3-metilglutaril (HMG CoA) reduktase, yakni enzim yang berperan pada sintesis kolesterol, terutama dalam hati. Obat-obat ini lebih efektif dibandingkan obat-obat penurun kolesterol lainnya dalam menurunkan kolesterol-LDL, tetapi kurang efektif dibanding fibrat dalam menurunkan trigliserida.

Efek samping

Efek samping yang paling sering timbul saat konsumsi statin adalah nyeri kepala, sulit tidur, kemerahan pada wajah, nyeri dan kelemahan pada otot, mual dan muntah, kembung, diare, konstipasi, penurunan kadar platelet.[2]

Beberapa orang mengalami keluhan rambut rontok, sensasi tertusuk jarum atau kebas di kulit, peradangan hati dan pankreas, masalah kulit seperti jerawat dan kemerahan, serta masalah seksual seperti disfungsi ereksi dan penurunan hasrat seksual bahkan statin dapat meningkatkan kadar gula darah dan memicu diabetes melitus tipe 2.[2][3]

Referensi

  1. ^ "Statins". nhs.uk (dalam bahasa Inggris). 2018-10-03. Diakses tanggal 2022-02-04. 
  2. ^ a b Bruce, Debra Fulghum; PhD. "Side Effects of Cholesterol-Lowering Statin Drugs". WebMD (dalam bahasa Inggris). Diakses tanggal 2022-02-04. 
  3. ^ "Statin side effects: Weigh the benefits and risks". Mayo Clinic (dalam bahasa Inggris). Diakses tanggal 2022-02-04. 

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