Jejaring metabolisme

Jejaring metabolisme adalah sekumpulan jalur-jalur yang saling terhubung dari reaksi biokimia yang berlangsung di dalam sel hidup yang menjadi tempat penyusunan senyawa yang diperlukan oleh sel tersebut untuk menjalankan fungsi selulernya (anabolisme) atau menghasilkan energi serta materi dari proses pemecahan biomolekul (katabolisme).^[1] Jejarin ini dapat digunakan untuk beberapa tujuan seperti memperkirakan hasil produksi optimal dari produk yang diinginkan berdasarkan pasokan satu atau lebih substrat, memodelkan distribusi fluks metabolik dalam suatu organisme dengan asumsi bahwa hasil biomassa sedang dimaksimalkan dan menilai dampak dari penambahan atau penghapusan reaksi dari jaringan tersebut.^[2] Jejaring metabolisme pada tingkat genom biasanya dibungan dari hulu yang dimulai dari genom organisme hingga reaksi enzimatik yang mereka hasilkan.^[3]

Referensi

^ Dräger, Andreas; Planatscher, Hannes (2013). Dubitzky, Werner; Wolkenhauer, Olaf; Cho, Kwang-Hyun; Yokota, Hiroki, ed. Metabolic Networks (dalam bahasa Inggris). New York, NY: Springer. hlm. 1249–1251. doi:10.1007/978-1-4419-9863-7_1277. ISBN 978-1-4419-9863-7.
^ Nielsen, J.; Bordel, S.; Nookaew, I. (2014). Genome-Scale Metabolic Models: A Link between Bioinformatics and Systems Biology. Elsevier. hlm. 165–173. doi:10.1016/b978-0-444-53632-7.01118-7. ISBN 978-0-444-53633-4.
^ Cottret, Ludovic; Frainay, Clément; Chazalviel, Maxime; Cabanettes, Floréal; Gloaguen, Yoann; Camenen, Etienne; Merlet, Benjamin; Heux, Stéphanie; Portais, Jean-Charles (2018-04-30). "MetExplore: collaborative edition and exploration of metabolic networks". Nucleic Acids Research. 46 (W1): W495–W502. doi:10.1093/nar/gky301. ISSN 0305-1048. PMC 6030842 . PMID 29718355. Pemeliharaan CS1: Format PMC (link)

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