GPR123

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ADGRA1

Pengidentifikasi

Alias

ADGRA1, GPR123, adhesion G protein-coupled receptor A1

ID eksternal

OMIM: 612302 MGI: 1277167 HomoloGene: 18582 GeneCards: ADGRA1

Lokasi gen (Manusia)

Kr.	Kromosom 10 (manusia)^[1]

Pita	10q26.3	Awal	133,087,924 bp^[1]
Pita	10q26.3	Akhir	133,131,675 bp^[1]

Lokasi gen (Tikus)

Kr.	Kromosom 7 (tikus)^[2]

Pita	7 F4\|7 84.89 cM	Awal	139,414,090 bp^[2]
Pita	7 F4\|7 84.89 cM	Akhir	139,458,004 bp^[2]

Ontologi gen
Fungsi molekuler	• G protein-coupled receptor activity • transmembrane signaling receptor activity • signal transducer activity
Komponen seluler	• komponen integral membran • membran • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse
Proses biologis	• G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • GO:0072468 signal transduction
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


84435


52389

Ensembl


ENSG00000197177


ENSMUSG00000025475

UniProt


Q86SQ6


Q8C4G9

RefSeq (mRNA)


NM_001083909 NM_001291085 NM_032422


NM_177469

RefSeq (protein)


NP_001077378 NP_001278014


NP_803420

Lokasi (UCSC)

Chr 10: 133.09 – 133.13 Mb

Chr 7: 139.41 – 139.46 Mb

Pencarian PubMed

^[3]

^[4]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

GPR123 (nama resmi: ADGRA1) adalah protein pada manusia disandi oleh gen GPR123.^[5]^[6] GPR123 adalah anggota dari keluarga reseptor GPCR adhesi. Anggota keluarga biasanya ditandai dengan daerah ekstraseluler diperpanjang dengan sejumlah variabel domain protein digabungkan ke domain TM7 melalui domain dikenal sebagai domain GAIN (GPCR-Autoproteolysis INducing).^[7]^[8]^[9]

Referensi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197177 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025475 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
^ "Entrez Gene: GPR123 G protein-coupled receptor 123". Diarsipkan dari versi asli tanggal 2023-07-26.
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182 . PMID 22333914.

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