Faktor NE


Faktor NE[1] (bahasa Inggris: Negative Regulatory Factor, NEF) adalah salah satu protein yang diekspresi oleh lentivirus, termasuk HIV dan SIV, yang disebut sebagai faktor virulen dan berfungsi untuk memanipulasi fungsi seluler dari inangnya sehingga didapat infeksi dan replikasi patogen.[2]

Faktor NE virus HIV mempertahankan kelangsungan hidup dari sel yang terinfeksi dengan menekan ekspresi molekul viral pada ekspresi MHC kelas I maupun kelas II, dan ekspresi molekul viral pada kluster diferensiasi CD4 dan CD28.[3]

Rujukan

  1. ^ Marcey D, Somple M, Silva N (2007-01-01). "HIV-1 Nef Protein". The Online Macromolecular Museum Exhibits. California Lutheran University. Diarsipkan dari versi asli tanggal 2008-09-17. Diakses tanggal 2008-08-06. 
  2. ^ Das SR, Jameel S (2005). "Biology of the HIV Nef protein" (PDF). Indian J. Med. Res. 121 (4): 315–32. PMID 15817946. Diarsipkan dari versi asli (PDF) tanggal 2017-08-10. Diakses tanggal 2010-04-02. 
  3. ^ Learmont JC, Geczy AF, Mills J, Ashton LJ, Raynes-Greenow CH, Garsia RJ, Dyer WB, McIntyre L, Oelrichs RB, Rhodes DI, Deacon NJ, Sullivan JS' (1999). "Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort". N. Engl. J. Med. 340 (22): 1715–22. doi:10.1056/NEJM199906033402203. PMID 10352163. 


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